Document Detail

The stability of lymphocytic beta 1,4-galactosyltransferase expression during pregnancy and lactation.
MedLine Citation:
PMID:  9042426     Owner:  NLM     Status:  MEDLINE    
The authors used murine pregnancy as a model to investigate the regulation of IgG glycosylation. Pregnancy is associated with decreased levels of circulating IgG. The oligosaccharides on this IgG from late (day 15), but not early (day 8), pregnant Balb/c mice exhibited increased levels of terminal galactose. The levels remained elevated 8 days post-partum in lactating mice. Nonetheless, splenic beta 1, 4-GalTase mRNA and enzyme activity remained relatively constant throughout pregnancy and into lactation. This was in contrast to a pregnancy-associated increase in mammary gland beta 1,4-GalTase mRNA. Thus the increased IgG galactose levels seen in pregnancy are regulated by mechanisms which are independent of transcriptional control of beta 1,4-GalTase expression.
P A Jeddi; J Keusch; P M Lydyard; P J Delves
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  45     ISSN:  0300-9475     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-03-26     Completed Date:  1997-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Department of Immunology, University College London Medical School, UK.
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MeSH Terms
B-Lymphocytes / enzymology*
Cells, Cultured
Galactose / metabolism
Gene Expression Regulation, Enzymologic*
Immunoglobulin G / analysis,  metabolism
Lactation / genetics,  metabolism*
Mice, Inbred BALB C
N-Acetyllactosamine Synthase / genetics*,  metabolism
Pregnancy, Animal / blood,  genetics,  metabolism*
RNA, Messenger / analysis,  metabolism
Ribonucleases / pharmacology
Spleen / cytology
Transcription, Genetic
Reg. No./Substance:
0/Immunoglobulin G; 0/RNA, Messenger; 26566-61-0/Galactose; EC Synthase; EC 3.1.-/Ribonucleases

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