| The stability of benzodiazepines in saliva. | |
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MedLine Citation:
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PMID: 3357364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The stability of some selected benzodiazepines in saliva has been studied. The benzodiazepines nitrazepam and clonazepam were found to be unstable in saliva at room temperature and nitrazepam was converted into 7-aminonitrazepam. The conversion rate of nitrazepam was strongly dependent on the composition of the subject's saliva. Nitro-reduction may complicate the use of saliva in epidemiological studies on drugs and driving. This could occur particularly if saliva drug concentrations are to be used as a quantitative measure of driving performance. |
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Authors:
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B J Hart; J Wilting; J J de Gier |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Methods and findings in experimental and clinical pharmacology Volume: 10 ISSN: 0379-0355 ISO Abbreviation: Methods Find Exp Clin Pharmacol Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-05-16 Completed Date: 1988-05-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7909595 Medline TA: Methods Find Exp Clin Pharmacol Country: SPAIN |
Other Details:
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Languages: eng Pagination: 21-6 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Chemistry, Subfaculty of Pharmacy, University of Utrecht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Benzodiazepines
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analysis* Drug Stability Humans Male Nitrazepam / analogs & derivatives, analysis Saliva / chemistry* Specimen Handling |
| Chemical | |
Reg. No./Substance:
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12794-10-4/Benzodiazepines; 146-22-5/Nitrazepam; 4928-02-3/7-aminonitrazepam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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