Document Detail

The stability of benzodiazepines in saliva.
MedLine Citation:
PMID:  3357364     Owner:  NLM     Status:  MEDLINE    
The stability of some selected benzodiazepines in saliva has been studied. The benzodiazepines nitrazepam and clonazepam were found to be unstable in saliva at room temperature and nitrazepam was converted into 7-aminonitrazepam. The conversion rate of nitrazepam was strongly dependent on the composition of the subject's saliva. Nitro-reduction may complicate the use of saliva in epidemiological studies on drugs and driving. This could occur particularly if saliva drug concentrations are to be used as a quantitative measure of driving performance.
B J Hart; J Wilting; J J de Gier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  10     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-05-16     Completed Date:  1988-05-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  21-6     Citation Subset:  IM    
Department of Pharmaceutical Chemistry, Subfaculty of Pharmacy, University of Utrecht, The Netherlands.
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MeSH Terms
Benzodiazepines / analysis*
Drug Stability
Nitrazepam / analogs & derivatives,  analysis
Saliva / chemistry*
Specimen Handling
Reg. No./Substance:
12794-10-4/Benzodiazepines; 146-22-5/Nitrazepam; 4928-02-3/7-aminonitrazepam

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