| A spoke in the wheel: calcium spikes disrupt yeast cell cycle. | |
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MedLine Citation:
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PMID: 18414024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A prerequisite of calcium signaling is the maintenance of cytoplasmic free Ca(2+) within a narrow, sub-micromolar range, compatible with cell viability. A variety of stress inducing agents and drugs can lead to a disruption of calcium homeostasis with ensuing toxicity. Amiodarone, an anti-arrhythmic drug with broad range microbicidal effect, has been shown to trigger a calcium burst in the yeast Saccharomyces cerevisiae. Recently, we reported that amiodarone elicits a starvation response, blocks cell cycle progression at multiple stages and represses the transcription of cell cycle genes. Here, we examine the connections between Ca(2+)-calcineurin signaling, nutrient sensing and regulation of the cell cycle. |
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Authors:
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Yong-Qiang Zhang; Rajini Rao |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2008-01-14 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 7 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-28 Completed Date: 2008-06-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 870-3 Citation Subset: IM |
Affiliation:
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Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amiodarone
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pharmacology* Calcineurin / metabolism* Calcium / metabolism* Cell Cycle / drug effects, physiology* Cytoplasm / chemistry Gene Expression Regulation, Fungal / drug effects, physiology* Models, Biological Saccharomyces cerevisiae / drug effects, metabolism* Signal Transduction / drug effects, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01AI065983/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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1951-25-3/Amiodarone; 7440-70-2/Calcium; EC 3.1.3.16/Calcineurin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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