| Is splenectomy a dyslipidemic intervention? Experimental response of serum lipids to different diets and operations. | |
| | |
MedLine Citation:
|
PMID: 18942648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Spleen removal may be recommended during organ transplantation in ABO-incompatible recipients as well as for hypoperfusion of the grafted liver, besides conventional surgical indications, but elevation of serum lipids has been observed in certain contexts. Aiming to analyze the influence of two dietary regimens on lipid profile, an experimental study was conducted. METHODS: Male Wistar rats (n = 86, 333.0 +/- 32.2 g) were divided in four groups: group 1: controls; group 2: sham operation; group 3: total splenectomy; group 4: subtotal splenectomy with upper pole preservation; subgroups A (cholesterol reducing chow) and B (cholesterol-rich mixture) were established, and diet was given during 90 days. Total cholesterol (Tchol), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and triglycerides were documented. RESULTS: After total splenectomy, hyperlipidemia ensued with cholesterol-reducing chow. Tchol, LDL, VLDL, triglycerides, and HDL changed from 56.4 +/- 9.2, 24.6 +/- 4.7, 9.7 +/- 2.2, 48.6 +/- 11.1, and 22.4 +/- 4.3 mg/dL to 66.9 +/- 11.4, 29.9 +/- 5.9, 10.9 +/- 2.3, 54.3 +/- 11.4, and 26.1 +/- 5.1 mg/dL, respectively. Upper pole preservation inhibited abnormalities of Tchol, HDL, VLDL, and triglycerides, and LDL decreased (23.6 +/- 4.9 vs. 22.1 +/- 5.1, P = 0.002). Higher concentrations were triggered by splenectomy and cholesterol-enriched diet (Tchol 59.4 +/- 10.1 vs. 83.9 +/- 14.3 mg/dL, P = 0.000), and upper-pole preservation diminished without abolishing hyperlipidemia (Tchol 55.9 +/- 10.0 vs. 62.3 +/- 7.8, P = 0.002). CONCLUSIONS: After splenectomy, hyperlipidemia occurred with both diets. Preservation of the upper pole tended to correct dyslipidemia in modality A and to attenuate it in subgroup B. |
| | |
Authors:
|
Danilo N S Paulo; Isabel Cal Paulo; Alvaro A C Morais; Mitre Kalil; Alvino J Guerra; Geraldo L Colnago; Joel Faintuch |
Related Documents
:
|
3958608 - Compensatory mechanisms governing the concentration of plasma low density lipoprotein. 15285698 - Dyslipidemia in visceral obesity: mechanisms, implications, and therapy. 8501728 - Effects of pregnancy and lactation on plasma lipid and lipoprotein concentrations, lipo... 227218 - Abnormal fat metabolism in chronic renal failure. 10872898 - The effect of vitamin e and vitamin c supplementation on ldl oxidizability and neutroph... 6673988 - Differential effects of dietary caloric and protein restriction in the aging rat. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Microsurgery Volume: 29 ISSN: 1098-2752 ISO Abbreviation: Microsurgery Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-02-09 Completed Date: 2009-06-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8309230 Medline TA: Microsurgery Country: United States |
Other Details:
|
Languages: eng Pagination: 154-60 Citation Subset: IM |
Copyright Information:
|
(c) 2008 Wiley-Liss, Inc. |
Affiliation:
|
Department of Surgery, Santa Casa de Misericordia de Vitoria, EMESCAM Medical School, Vitoria, Brazil. Icpaulo@unimedvitoria.com.br |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cholesterol / blood* Cholesterol, Dietary / administration & dosage* Dyslipidemias / prevention & control* Hyperlipidemias / epidemiology Lipoproteins, LDL / blood Lipoproteins, VLDL / blood Male Postoperative Complications / epidemiology Rats Rats, Wistar Splenectomy* / adverse effects, methods Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
|
0/Cholesterol, Dietary; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of regeneration results of prefabricated nerve graft, autogenous nerve graft, and vein gr...
Next Document: Microvascular surgery in the previously operated and irradiated neck.