| Is the spleen a preferential site of blood cell production in the human fetus? | |
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MedLine Citation:
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PMID: 11322298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Information about the status of the spleen as a preferential site of blood cell production in the human fetus is relevant to generalizations about the ontogeny of haematopoietic microenvironments and to speculations about the pathogenesis of myeloid metaplasia. Such information has been accumulated in a comparison of populations of blood cell precursors derived from the blood, the spleens and the livers of human fetuses during the fourth, fifth, sixth and seventh months of gestation. During this period, the spleen does not contain populations of erythroblasts or granulocyte precursors that could not have been derived from the blood. It is inferred that in the human fetus the spleen is not a preferential site of blood cell production between the fourth and seventh months of gestation. Like any other site, the spleen may however accommodate intravascular blood cell precursors, which may proliferate and differentiate in human fetal blood. |
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Authors:
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D B Thomas |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia Volume: 100 Suppl 1 ISSN: 1122-6714 ISO Abbreviation: Ital J Anat Embryol Publication Date: 1995 |
Date Detail:
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Created Date: 2001-04-26 Completed Date: 2001-06-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9612303 Medline TA: Ital J Anat Embryol Country: Italy |
Other Details:
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Languages: eng Pagination: 245-51 Citation Subset: IM |
Affiliation:
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School of Biology and Medical Sciences, University of St. Andrews, Scotland, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Cells
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cytology*,
metabolism Fetus / cytology*, embryology*, metabolism Hematopoiesis, Extramedullary / physiology* Hematopoietic Stem Cells / cytology, metabolism Humans Spleen / cytology*, embryology*, metabolism |
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