|Is spleen circulation impaired in systemic sclerosis and what is the role of liver fibrosis?|
|PMID: 21472128 Owner: NLM Status: MEDLINE|
|AIM: To investigate the spleen vascular involvement and the presence of liver fibrosis in a population of subjects with established systemic sclerosis (SSc).
METHODS: In a cross-sectional fashion, 17 patients with SSc were compared with 18 patients suffering from hepatitis C virus (HCV)-related liver cirrhosis, grade A and B Child-Pugh classification. Eighteen non elderly subjects, apparently healthy, were used as the control group. Splenic artery resistivity index (SARI) at Doppler ultrasound, transient elastography of liver and nailfold capillaroscopy were the main outcomes.
RESULTS: Transient elastography values of SSc patients were similar to those of controls; 5.2 ± 1.1 vs 4.5 ± 1, (P = 0.07). Median Alanine amino transferase (ALT) concentrations of cirrhotic patients were greater than those of controls and SSc patients, i.e. 66.5 (36-89) U/L vs 29 (22-34) U/L and 31 (22-41) U/L, respectively, (P = 0.005). SARI determinations in cirrhotic patients, although significantly higher than those found in controls and SSc patients, showed some degree of overlap with SSc patients, i.e. 0.59 vs 0.52 and 0.57, respectively, (P = 0.04). Mean systolic blood pressure was significantly higher in SSc patients than in cirrhotics and controls, i.e. 142 mmHg vs 128.2 mmHg and 127 mmHg, respectively, (P = 0.005). Mean diastolic blood pressure behaved in a similar fashion, i.e. 84 mmHg vs 72.2 mmHg and 76.9 mmHg (P = 0.005). Nailfold Capillaroscopy grades and diastolic blood pressure values correlated well with SARI results.
CONCLUSION: An enhanced resistivity of the splenic artery was found in patients suffering from SSc; they did not have evidence of splenomegaly as well as no liver fibrosis or any other form of liver damage.
|Giovanni Tarantino; Angelo Spanò; Gabriella Loi; Anna Parisi; Marianna Tarantino; Giuseppina Brancaccio; Giovanni Battista Gaeta; Antonio Riccio|
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|Type: Journal Article; Research Support, Non-U.S. Gov't|
|Title: World journal of gastroenterology : WJG Volume: 17 ISSN: 2219-2840 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2011 Mar|
|Created Date: 2011-04-07 Completed Date: 2011-07-25 Revised Date: 2014-05-20|
Medline Journal Info:
|Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China|
|Languages: eng Pagination: 1606-13 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Analysis of Variance
Capillaries / physiopathology
Elasticity Imaging Techniques
Fingers / blood supply
Hepatitis C / complications
Liver Cirrhosis / diagnosis, physiopathology*, virology
Scleroderma, Systemic / complications, diagnosis, physiopathology*
Spleen / blood supply*
Splenic Artery / physiopathology*, ultrasonography
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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