| The spiral ganglion and cochlear nuclei of deafness mice. | |
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MedLine Citation:
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PMID: 4030509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Deafness mice (dn/dn) never develop hearing, but, except for the associated physical defects, have no other known abnormalities. For this study, cochleas and brains of five adult homozygotes (dn/dn) and five adult heterozygotes (+/dn), matched by weight and sex, were prepared for serial section light microscopy. In the homozygotes, the organ of Corti was totally degenerated basally, gradually improving toward the apex where supporting cells, border cells and pillar cells were present; however, the stria vascularis was dystrophic in the apex. The saccular macula was atrophied or dystrophic in seven of the ten homozygote ears. The homozygotes had only 23% of the number of spiral ganglion cells found in the heterozygotes, but they appeared robust. In six of the ears of each group there was clumping of apical spiral ganglion neurons. In the homozygotes, the volume of Rosenthal's canal was 121%, that of the dorsal nuclei was 90%, and that of the ventral cochlear nuclei was 63% of the comparable volumes in heterozygotes. The globular cells of the homozygote ventral cochlear nucleus were 72% of the size of those of heterozygotes. These quantitative morphological abnormalities of the homozygote spiral ganglion and cochlear nuclei may result from organ of Corti atrophy. |
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Authors:
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D B Webster |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hearing research Volume: 18 ISSN: 0378-5955 ISO Abbreviation: Hear. Res. Publication Date: 1985 Apr |
Date Detail:
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Created Date: 1985-10-07 Completed Date: 1985-10-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7900445 Medline TA: Hear Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 19-27 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cochlea / pathology* Cochlear Nerve / pathology* Deafness / genetics, pathology* Ear, Inner / pathology Heterozygote Homozygote Mice Mice, Neurologic Mutants Organ of Corti / pathology Pons / pathology* Spiral Ganglion / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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NS-19238/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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