Document Detail


The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation.
MedLine Citation:
PMID:  15289666     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The centromere defines where on a chromosome the kinetochores assemble. Kinetochores, large protein structures, mediate chromosome segregation during mitosis and meiosis by performing three key functions. Firstly, kinetochores attach chromosomes to the microtubule spindle apparatus. Secondly, kinetochores co-ordinate microtubule dynamics to allow chromosomes to move along the spindle. Lastly, kinetochores generate the 'wait' signal which prevents anaphase onset until all the chromosomes are correctly aligned on the spindle. This signal forms part of the spindle checkpoint mechanism, a highly conserved cell cycle checkpoint which maintains the accuracy of the chromosome segregation process. This article provides a brief historical overview before focusing on some of the outstanding issues and more recent developments in the field.
Authors:
Stephen S Taylor; Maria I F Scott; Andrew J Holland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology     Volume:  12     ISSN:  0967-3849     ISO Abbreviation:  Chromosome Res.     Publication Date:  2004  
Date Detail:
Created Date:  2004-08-03     Completed Date:  2005-02-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9313452     Medline TA:  Chromosome Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  599-616     Citation Subset:  IM    
Affiliation:
School of Biological Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom. stephen.taylor@man.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Calcium-Binding Proteins / metabolism
Cell Cycle Proteins
Chromosome Segregation*
Humans
Kinetochores / metabolism*
Mitotic Spindle Apparatus / metabolism,  physiology*
Molecular Sequence Data
Neoplasms / genetics
Protein Kinases / metabolism,  physiology
Protein-Serine-Threonine Kinases
Repressor Proteins
Chemical
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/Cell Cycle Proteins; 0/MAD2L1 protein, human; 0/Repressor Proteins; EC 2.7.-/Protein Kinases; EC 2.7.11.1/Bub1 spindle checkpoint protein; EC 2.7.11.1/Protein-Serine-Threonine Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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