Document Detail


The spinal cord lesion in human fetuses with myelomeningocele: implications for fetal surgery.
MedLine Citation:
PMID:  9094015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently produced experimental evidence suggests that secondary traumatic injury and degenerative changes, acquired in utero, to the openly exposed neural tissue may be primarily responsible for the massive neurological deficit associated with myelomeningocele (MMC). The goal of this study was to examine the morphology of human fetuses with MMC to determine if acquired trauma to the spinal cord could be identified. The MMC lesions with surrounding tissues from 10 human fetuses ranging in gestational age between 19 and 23 weeks were prepared with serial histological sections. The MMC lesions were characterized by an open vertebral arch, an open dura mater fused laterally to the dermis, and an open pia mater fused laterally to the epidermis. The spinal cord was exposed, without any meningeal, bony, or cutaneous covering, and was resting on the dorsal aspect of the abnormal arachnoid sac created by the fusion of the meninges to the cutaneous tissues. The exposed neural tissue had undergone varying degrees of recent traumatic injury as a result of its exposed position, ranging from nearly complete preservation of neural elements in four cases to nearly complete loss in two cases. The neural tissue remaining in the MMC with partial loss contained hemorrhages and abrasions from recent injury, suggesting that injury occurred during passage through the birth canal. The presence of dorsal and ventral parts of the cord with nerve roots and ganglia demonstrated that these structures had formed during development and that the loss of tissue by injury was a secondary change. The results support the concept that performing in utero surgery could protect the exposed but initially well-developed and uninjured cord, prevent secondary neural injury, and preserve neural function in the human fetus with myelomeningocele.
Authors:
M Meuli; C Meuli-Simmen; G M Hutchins; M J Seller; M R Harrison; N S Adzick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  32     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-24     Completed Date:  1997-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  448-52     Citation Subset:  IM    
Affiliation:
Department of Surgery, University Children's Hospital, Zurich, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Brain Damage, Chronic / embryology,  etiology*,  pathology
Embryonic and Fetal Development
Female
Fetal Diseases / surgery
Humans
Male
Meningomyelocele / complications*,  pathology,  surgery
Spinal Cord / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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