Document Detail


The spectrum of statin myopathy.
MedLine Citation:
PMID:  24061077     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: This review discusses the spectrum of myopathies associated with statin use, with special attention given to a recently identified statin-associated autoimmune-necrotizing myopathy. The clinical characteristics of these patients, pathologic findings, associated autoantibody and immunogenetic risk factors are discussed.
RECENT FINDINGS: In the past several years, a novel form of autoimmunemyopathy associated with statin use has been described. Patients with this form of myositis have unique clinical, pathologic and pathophysiologic features when compared with those with self-limited statin toxic myopathy. An autoantibody directed against HMG-CoA reductase (HMGCR), the pharmacologic target of statins, characterizes the disease and can be used in clinical practice to identify these patients and direct therapy. Still, many questions remain to be answered regarding the pathogenic mechanisms at play, risk factors for developing the disease, long-term prognosis and effects of rechallenge with statins or other cholesterol-lowering drugs.
SUMMARY: Statins can cause a spectrum of muscle diseases, most of which are self-limited and improve with discontinuation of the offending agent. In a subgroup, an autoimmune necrotizing myopathy develops that persists after discontinuation of statins. Specific autoantibody testing can help identify these patients in clinical practice and determine the need for immunosuppressive therapy.
Authors:
Payam Mohassel; Andrew L Mammen
Related Documents :
2644067 - Metabolic and nutritional aspects of weaning from mechanical ventilation.
10714417 - Sleep-related breathing disorders in acute respiratory failure assisted by non-invasive...
15154317 - Shifting care of chronic ventilator-dependent patients from the intensive care unit to ...
11742967 - Qualitative studies on the patient's experience of weaning from mechanical ventilation.
4066107 - Treatment of alopecia areata with topical nitrogen mustard.
24353637 - Pre dialysis care and types of vascular access employed in incident hemodialysis patien...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  25     ISSN:  1531-6963     ISO Abbreviation:  Curr Opin Rheumatol     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-09-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  747-52     Citation Subset:  IM    
Affiliation:
aDepartment of Neurology bDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  What does global gene expression profiling tell us about the pathogenesis of systemic sclerosis?
Next Document:  Update in juvenile myositis.