| The spectrum of plant and animal sterols in different oil-derived intravenous emulsions. | |
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MedLine Citation:
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PMID: 20049583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intravenous lipid constituents have different effects on various biological processes. Some of these effects are protective, while others are potentially adverse. Phytosterols, in particular, seem to be implicated with parenteral nutrition-associated cholestasis. The aim of this study is to determine the amount of plant and animal sterols present in lipid formulations derived from different oil sources. To this end, animal (cholesterol) and plant (beta-sitosterol, campesterol, and stigmasterol) sterols in seven different commercially available intravenous lipid emulsions (ILEs) were quantified by capillary gas chromatography after performing a lipid extraction procedure. The two major constituents of the lipid emulsions were cholesterol (range 14-57% of total lipids) and beta-sitosterol (range 24-55%), followed by campesterol (range 8-18%) and stigmasterol (range 5-16%). The fish oil-derived formulation was an exception, as it contained only cholesterol. The mean values of the different sterols were statistically different across ILEs (P = 0.0000). A large percentage of pairwise comparisons were also statistically significant (P = 0.000), most notably for cholesterol and stigmasterol (14 out of 21 for both), followed by campesterol (12 out 21) and beta-sitosterol (11 out 21). In conclusion, most ILEs combined significant amounts of phytosterols and cholesterol. However, their phytosterols:cholesterol ratios were reversed compared to the normal human diet. |
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Authors:
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Maria Luisa Forchielli; Germana Bersani; Sara Tala; Gabriele Grossi; Cristina Puggioli; Massimo Masi |
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Publication Detail:
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Type: Journal Article Date: 2009-11-22 |
Journal Detail:
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Title: Lipids Volume: 45 ISSN: 1558-9307 ISO Abbreviation: Lipids Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-05 Completed Date: 2010-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: Germany |
Other Details:
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Languages: eng Pagination: 63-71 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, S Orsola-Malpighi, Medical School of Bologna, Via Massarenti 11, 40138 Bologna, Italy. luisa.forchielli@unibo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cholestasis
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chemically induced Cholesterol / analogs & derivatives, analysis Fat Emulsions, Intravenous / chemistry* Fish Oils / analysis Humans Parenteral Nutrition, Total / adverse effects Phytosterols / analysis* Sitosterols / analysis Stigmasterol / analysis |
| Chemical | |
Reg. No./Substance:
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0/Fat Emulsions, Intravenous; 0/Fish Oils; 0/Phytosterols; 0/Sitosterols; 474-62-4/campesterol; 57-88-5/Cholesterol; 5779-62-4/sitosterol; 83-48-7/Stigmasterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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