Document Detail


The spectrum of persistence of testicular blastema and ectopic testicular parenchyma: a possible result of focal delay in gonadal development.
MedLine Citation:
PMID:  17406892     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sex-cord formation and organization are important steps in testicular development and depend on adequate interactions between mesenchymal cells, pre-Sertoli cells, and germ cells. These elements form the testicular blastema, the precursor of the testicular parenchyma, morphologically characterized by poorly organized sex cords and mesenchymal components. Here, we study two uncommon testicular lesions, unrelated to other gonadal anomalies. In the first group, we describe the features of persistence of testicular blastema in three fetal autopsy cases, discussing its possible pathogenesis and clinical importance. In the second, we analyze 11 cases of ectopic testicular parenchyma in the tunica albuginea, an uncommon benign condition of uncertain clinical significance, whose main differential diagnosis is gonadal dysgenesis. Based on their similar topography within the testis, and on their possibly shared embryological origin, we propose that both lesions may represent the two extremes of a maldevelopmental spectrum resulting from a focal delay in testicular development.
Authors:
Mariana M Cajaiba; Eugenia García-Fernández; Miguel Reyes-Múgica; Manuel Nistal
Publication Detail:
Type:  Journal Article     Date:  2007-04-04
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  451     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-30     Completed Date:  2007-11-02     Revised Date:  2007-11-26    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
Affiliation:
Department of Pathology, Hospital La Paz/Universidad Autónoma de Madrid, Madrid, Spain. mmcajaiba@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Child, Preschool
Choristoma / pathology*
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Pregnancy
Testis / embryology,  pathology*
Comments/Corrections
Erratum In:
Virchows Arch. 2007 Oct;451(4):861

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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