| The spectrum of nonmotor symptoms in early Parkinson disease. | |
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MedLine Citation:
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PMID: 23319473 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Nonmotor symptoms (NMS) are common in patients with established Parkinson disease (PD) but their frequency in early PD has not been extensively studied. Our aim was to determine the frequency of NMS in a cohort of patients with newly diagnosed PD. METHODS: A total of 159 patients with early PD and 99 healthy controls participated in this study. NMS were screened for using the nonmotor symptom questionnaire. Other assessments included measures of motor disability (Movement Disorders Society-revised unified Parkinson's disease rating scale [MDS-UPDRS]), disease severity (Hoehn & Yahr staging), depression (geriatric depression scale), and global cognitive function (Mini-mental state examination and Montreal cognitive assessment). RESULTS: The PD group reported a significantly greater number of NMS compared with controls (8.4 [4.3] vs. 2.8 [2.6]). In the PD group, the most commonly experienced NMS were excessive saliva, forgetfulness, urinary urgency, hyposmia, and constipation. Patients with higher MDS-UPDRS III scores and those with the postural instability gait subtype experienced a greater number of NMS. CONCLUSION: NMS are common in early PD and reflect the multisystem nature of the disorder. Even in the earliest stages of PD, NMS may be detrimental to patients' functional status and sense of well-being. |
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Authors:
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Tien K Khoo; Alison J Yarnall; Gordon W Duncan; Shirley Coleman; John T O'Brien; David J Brooks; Roger A Barker; David J Burn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 80 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-15 Completed Date: 2013-03-07 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 276-81 Citation Subset: AIM; IM |
Affiliation:
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Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antiparkinson Agents / therapeutic use Autonomic Nervous System Diseases / epidemiology, etiology Cognition Cohort Studies Female Gait Disorders, Neurologic / epidemiology, etiology, physiopathology Humans Levodopa / therapeutic use Male Mental Disorders / epidemiology, etiology Middle Aged Nervous System Diseases / epidemiology, etiology Parkinson Disease / complications*, physiopathology*, psychology Questionnaires |
| Grant Support | |
ID/Acronym/Agency:
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//Department of Health |
| Chemical | |
Reg. No./Substance:
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0/Antiparkinson Agents; 0/Levodopa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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