Document Detail


The spectrum of nonmotor symptoms in early Parkinson disease.
MedLine Citation:
PMID:  23319473     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Nonmotor symptoms (NMS) are common in patients with established Parkinson disease (PD) but their frequency in early PD has not been extensively studied. Our aim was to determine the frequency of NMS in a cohort of patients with newly diagnosed PD.
METHODS: A total of 159 patients with early PD and 99 healthy controls participated in this study. NMS were screened for using the nonmotor symptom questionnaire. Other assessments included measures of motor disability (Movement Disorders Society-revised unified Parkinson's disease rating scale [MDS-UPDRS]), disease severity (Hoehn & Yahr staging), depression (geriatric depression scale), and global cognitive function (Mini-mental state examination and Montreal cognitive assessment).
RESULTS: The PD group reported a significantly greater number of NMS compared with controls (8.4 [4.3] vs. 2.8 [2.6]). In the PD group, the most commonly experienced NMS were excessive saliva, forgetfulness, urinary urgency, hyposmia, and constipation. Patients with higher MDS-UPDRS III scores and those with the postural instability gait subtype experienced a greater number of NMS.
CONCLUSION: NMS are common in early PD and reflect the multisystem nature of the disorder. Even in the earliest stages of PD, NMS may be detrimental to patients' functional status and sense of well-being.
Authors:
Tien K Khoo; Alison J Yarnall; Gordon W Duncan; Shirley Coleman; John T O'Brien; David J Brooks; Roger A Barker; David J Burn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  80     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-15     Completed Date:  2013-03-07     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  276-81     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Antiparkinson Agents / therapeutic use
Autonomic Nervous System Diseases / epidemiology,  etiology
Cognition
Cohort Studies
Female
Gait Disorders, Neurologic / epidemiology,  etiology,  physiopathology
Humans
Levodopa / therapeutic use
Male
Mental Disorders / epidemiology,  etiology
Middle Aged
Nervous System Diseases / epidemiology,  etiology
Parkinson Disease / complications*,  physiopathology*,  psychology
Questionnaires
Grant Support
ID/Acronym/Agency:
J-0802//Parkinson's UK; MC_U120036861//Medical Research Council; //Department of Health
Chemical
Reg. No./Substance:
0/Antiparkinson Agents; 46627O600J/Levodopa
Comments/Corrections

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