Document Detail

The spectrum of neuromyelitis optica: a case of NMO with extensive brain stem involvement.
MedLine Citation:
PMID:  17427272     Owner:  NLM     Status:  MEDLINE    
Neuromyelitis optica (NMO), regarded as a distinct clinical entity from multiple sclerosis (MS), is generally characterized by demyelinating lesions involving optic nerves and spinal cord with sparing of the brain. We report a case with initial clinical, radiological and serological features consistent with NMO, but with concomitant extensively clinical and radiological involvement of the brain stem. Although there are well defined criteria for NMO that restricts the lesions to optic nerves and spinal cord, the case presented here and the review of literature support the idea that NMO may present as a spectrum of clinical and radiological entities rather than the confining clinical criteria that has been hitherto applied.
Martina Vendrame; S Ausim Azizi
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurological research     Volume:  29     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-04-11     Completed Date:  2007-05-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  32-5     Citation Subset:  IM    
Department of Neurology, 558 Parkinson Pavilion, 3401 North Broad Street Temple University, School of Medicine, Philadelphia, PA 19140, USA.
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MeSH Terms
Antibodies / blood
Autonomic Nervous System Diseases / etiology,  physiopathology
Biological Markers / blood
Brain Stem / pathology*,  physiopathology
Cerebrospinal Fluid / cytology
Diagnosis, Differential
Disease Progression
Immunoglobulins, Intravenous / therapeutic use
Leukocytosis / cerebrospinal fluid
Magnetic Resonance Imaging
Middle Aged
Motor Neurons / pathology
Nerve Fibers, Myelinated / pathology
Neural Pathways / pathology
Neuromyelitis Optica / blood,  cerebrospinal fluid,  diagnosis*
Spinal Cord / pathology,  physiopathology
Steroids / therapeutic use
Treatment Failure
Reg. No./Substance:
0/Antibodies; 0/Biological Markers; 0/Immunoglobulins, Intravenous; 0/Steroids

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