Document Detail

The spectrum of cow's milk allergy.
MedLine Citation:
PMID:  17433004     Owner:  NLM     Status:  MEDLINE    
Childhood cow's milk allergy is a diagnosis encompassing various syndromes. Antigen-immunoglobulin E (IgE) antibody interaction is classically involved in mast cell degranulation in IgE-mediated food allergy, while non-IgE mediated cow's milk allergy is mostly mediated by cellular mechanisms. The diagnosis of cow's milk allergy largely relies on a good knowledge of the clinical expression of the disease. In this educational review series, we describe three cases of cow's milk allergy, first a 7-yr-old girl with persisting IgE-mediated cow's milk allergy, second a 8-month-old boy with cow's milk induced flares of atopic dermatitis, and third a 6-yr-old boy with sheep and goat milk allergy, in the absence of cow's milk allergy. The cases are discussed and summarized with more general recommendations for the clinical management of cow's milk allergy.
Philippe A Eigenmann
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  18     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-16     Completed Date:  2007-06-26     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  265-71     Citation Subset:  IM    
Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland.
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MeSH Terms
Immunoglobulin E / blood*
Milk / adverse effects*
Milk Hypersensitivity / blood,  diagnosis*
Reg. No./Substance:
37341-29-0/Immunoglobulin E
Comment In:
Pediatr Allergy Immunol. 2008 May;19(3):275; author reply 276-8   [PMID:  18397412 ]

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