| The spectrum of coincident entities with small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) diagnosed by cytology. | |
| | |
MedLine Citation:
|
PMID: 20976208 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: The cytologic diagnosis of Small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) often relies on finding a small lymphoid population with the characteristic immunoprofile by ancillary testing. There are only a few reports of other processes identified with SLL/CLL. The aim of this study was to review the fine needle aspiration (FNA) and touch prep (TP) diagnoses of SLL/CLL in order to identify any coincident entities. MATERIALS AND METHODS: We retrospectively reviewed all FNA and TP cytology cases between January 2005 and May 2009 with a diagnosis of SLL/CLL to determine the presence of any coincident process. RESULTS: We identified 29 cases, including 23 FNAs and six TPs, from 23 patients. Ancillary studies were utilized in 97% of the cases, including flow cytometry (FC, 79%), immunohistochemistry (IHC, 55%), fluorescent in situ hybridization studies (24%) and special stains (7%). Coincident entities were identified in nine cases (31%) and included seven (28%) neoplastic entities (Hodgkin lymphoma [HL], adenocarcinoma, squamous cell carcinoma, seminoma) and two (7%) non-neoplastic entities (infection and immunoglobulin containing cells). Six cases (21%) suspicious for large cell transformation were also identified. CONCLUSION: In our review of SLL/CLL, coincident entities were present in 31% of the cases and included a spectrum of non-neoplastic and neoplastic processes. FC was the most frequently utilized ancillary test, but IHC provided important information by excluding a mantle cell lymphoma or confirming a coincident process. Thus, cytomorphologic evaluation in these patients is important due to the high risk of a coincident process that may not be apparent by FC alone and may require clinical management. |
| | |
Authors:
|
Hannah A Kastenbaum; Walid E Khalbuss; Raymond E Felgar; Ronald Stoller; Sara E Monaco |
Related Documents
:
|
15551358 - Human t-cell lymphotropic virus type 1 (htlv-1) and lymphoid malignancies in dominica: ... 9592988 - Persistent polyclonal b lymphocytosis with multiple bcl-2/igh rearrangements: a benign ... 8713288 - Environmental factors may regulate bcl2 associated lymphomagenesis: a very low incidenc... 12754588 - Burkitt-like lymphoma in an infant: a case report. 19829928 - Central retinal vein occlusion: a case report and review of the literature. 6459988 - Unbalanced robertsonian translocations associated with down's syndrome or patau's syndr... |
Publication Detail:
|
Type: Journal Article Date: 2010-10-11 |
Journal Detail:
|
Title: CytoJournal Volume: 7 ISSN: 1742-6413 ISO Abbreviation: Cytojournal Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101231642 Medline TA: Cytojournal Country: India |
Other Details:
|
Languages: eng Pagination: 20 Citation Subset: - |
Affiliation:
|
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Eosinophilic ascites due to severe eosinophilic ileitis.
Next Document: Management of complex avulsion injuries of the dorsum of the foot and ankle in pediatric patients by...