Document Detail


The spectrum of antineuronal autoantibodies in a series of neurological patients.
MedLine Citation:
PMID:  15140602     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study is to identify the range of neurological disorders expressing antineuronal antibodies, evaluate the number of different patterns of reactivity that can be detected, and analyse the contribution of these studies to the identification of subgroups of patients. The records of 882 patients were reviewed and their sera and cerebrospinal fluids tested for antineuronal antibodies. Patients were initially divided into four groups according to suspected clinical diagnosis. Autoantibodies were detected by immunohistochemistry, Western blot of gradient-separated neuronal and recombinant proteins and by RIA. Cerebellar degeneration and sensory neuropathies were the most common neurological disorders in which paraneoplastic-related anti-neuronal antibodies were detected. However, in addition to PCA1/anti-Yo and ANNA1/anti-Hu antibodies, we found other reactivities in six patients with cerebellar degeneration: anti-GAD in three females and atypical in the other cases. The widest range of different anti-neuronal antibodies was detected in patients with peripheral sensory neuropathy. Few patients with Stiff-Person syndrome, temporal lobe epilepsy and myoclonus harboured anti-GAD antibodies. Atypical antibodies were detected in single cases with motor neuron disorder and multiple system atrophy. No anti-neuronal antibodies were detected in patients with neurological complications of connective tissue disorders other than Sjögren's syndrome, or in neurological diseases other than motor neuron disease and multiple system atrophy. Our study shows that the spectrum of neurological disorders in which anti-neuronal antibodies can be detected is wider than previously thought. In addition, we found patterns of neuronal staining and Western blot reactivity that differed from those so far reported. This may permit identification of subgroups of patients in whom strategies directed at removing and/or suppressing antibody production could be of some benefit.
Authors:
M Vianello; R Vitaliani; R Pezzani; P Nicolao; C Betterle; G Keir; E J Thompson; B Tavolato; F Scaravilli; B Giometto
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  220     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-13     Completed Date:  2004-07-22     Revised Date:  2006-11-28    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  29-36     Citation Subset:  IM    
Affiliation:
Department of Neurological and Psychiatric Sciences, Second Neurological Clinic, University of Padua, via Facciolati 71, Padua 35127, Italy.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Neoplasm / metabolism
Autoantibodies / immunology*
Blotting, Western / methods
DNA-Binding Proteins / immunology,  metabolism
Female
Glutamate Decarboxylase / metabolism
Hu Paraneoplastic Encephalomyelitis Antigens
Humans
Immunohistochemistry / methods
Male
Neoplasm Proteins / immunology,  metabolism
Nerve Tissue Proteins
Nervous System Diseases / classification,  immunology*
Neurons / immunology*
RNA-Binding Proteins / immunology,  metabolism
Radioimmunoassay / methods
Chemical
Reg. No./Substance:
0/Antibodies, Neoplasm; 0/Autoantibodies; 0/CDR2 protein, human; 0/DNA-Binding Proteins; 0/Hu Paraneoplastic Encephalomyelitis Antigens; 0/Neoplasm Proteins; 0/Nerve Tissue Proteins; 0/RNA-Binding Proteins; EC 4.1.1.15/Glutamate Decarboxylase

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