Document Detail

The spectrum of Spitz nevi: a clinicopathologic study of 83 cases.
MedLine Citation:
PMID:  16301385     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To achieve a clinicopathologic classification of Spitz nevi by comparing their clinical, dermoscopic, and histopathologic features. DESIGN: Eighty-three cases were independently reviewed by 3 histopathologists and preliminarily classified into classic or desmoplastic Spitz nevus (CDSN, n = 11), pigmented Spitz nevus (PSN, n = 14), Reed nevus (RN, n = 16), or atypical Spitz nevus (ASN, n = 14); the remaining 28 cases were then placed into an intermediate category (pigmented Spitz-Reed nevus, PSRN) because a unanimous diagnosis of either PSN or RN was not reached. SETTING: University dermatology and pathology departments and general hospital pathology departments. PATIENTS: A sample of subjects with excised melanocytic lesions. MAIN OUTCOME MEASURE: Frequency of dermoscopic patterns within the different histopathologic subtypes of Spitz nevi. RESULTS: Overlapping clinical, dermoscopic, and histopathologic findings were observed among PSN, RN, and PSRN, thereby justifying their inclusion into the single PSRN diagnostic category. Asymmetry was the most frequent indicator of histopathologic ASN (79%; n = 11); in only 4 cases did dermoscopic asymmetry show no histopathologic counterpart, and in those cases the discrepancy was probably the result of an artifact of the gross sampling technique carried out with no attention to the dermoscopic features. CONCLUSIONS: Among Spitz nevi, histopathologic distinction between PSN and RN is difficult, not reproducible, and may be clinically useless. A simple clinicopathologic classification of these neoplasms might therefore be structured as CDSN, PSRN, and ASN. Asymmetry should be assessed using both dermoscopic and histopathologic analysis, and reliability in histopathologic diagnosis may be enhanced by the simultaneous evaluation of the corresponding dermoscopic images.
Gerardo Ferrara; Giuseppe Argenziano; H Peter Soyer; Sergio Chimenti; Arturo Di Blasi; Giovanni Pellacani; Ketty Peris; Domenico Piccolo; Pietro Rubegni; Stefania Seidenari; Stefania Staibano; Iris Zalaudek; Gaetano De Rosa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  141     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-22     Completed Date:  2005-12-09     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1381-7     Citation Subset:  AIM; IM    
Pathologic Anatomy Service, Gaetano Rummo General Hospital, Benevento, Italy.
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MeSH Terms
Child, Preschool
Italy / epidemiology
Medical Records
Middle Aged
Nevus, Epithelioid and Spindle Cell / diagnosis,  epidemiology*,  etiology,  pathology
Retrospective Studies
Skin Neoplasms / diagnosis,  epidemiology*,  etiology,  pathology

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