Document Detail


The spectral tuning in the short wavelength-sensitive type 2 pigments.
MedLine Citation:
PMID:  12657470     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using site-directed mutagenesis and multiple regression analysis, we have studied the molecular genetics and evolution of short wavelength-sensitive (SWS2) pigments in vertebrates. These analyses suggest that the SWS2 pigment in the vertebrate ancestor had the wavelength of maximum absorption (lambda(max)) of approximately 440 nm and that various lambda(max)'s of the contemporary SWS2 pigments in vertebrates are caused mainly by additive effects of amino acid replacements at ten sites.
Authors:
Shozo Yokoyama; Takashi Tada
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gene     Volume:  306     ISSN:  0378-1119     ISO Abbreviation:  Gene     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-26     Completed Date:  2003-05-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7706761     Medline TA:  Gene     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  91-8     Citation Subset:  IM    
Affiliation:
Department of Biology, Biological Research Laboratories, Syracuse University, 130 College Place, Syracuse, NY 13244, USA. syokoyam@mailbox.syr.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Mutagenesis, Site-Directed
Mutation
Phylogeny
Retinal Pigments / chemistry*,  genetics*
Spectrophotometry
Vertebrates
Grant Support
ID/Acronym/Agency:
GM42379/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Retinal Pigments

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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