Document Detail

The specification of heart mesoderm occurs during gastrulation in Xenopus laevis.
MedLine Citation:
PMID:  2598816     Owner:  NLM     Status:  MEDLINE    
The establishment of heart mesoderm during Xenopus development has been examined using an assay for heart differentiation in explants and explant combinations in culture. Previous studies using urodele embryos have shown that the heart mesoderm is induced by the prospective pharyngeal endoderm during neurula and postneurula stages. In this study, we find that the specification of heart mesoderm must begin well before the end of gastrulation in Xenopus embryos. Explants of prospective heart mesoderm isolated from mid- or late neurula stages were capable of heart formation in nearly 100% of cases, indicating that the specification of heart mesoderm is complete by midneurula stages. Moreover, inclusion of pharyngeal endoderm had no statistically significant effect upon either the frequency of heart formation or the timing of the initiation of heartbeat in explants of prospective heart mesoderm isolated after the end of gastrulation. When the superficial pharyngeal endoderm was removed at the beginning of gastrulation, experimental embryos formed hearts, as did explants of prospective heart mesoderm from such embryos. These results indicate that the inductive interactions responsible for the establishment of heart mesoderm occur prior to the end of gastrulation and do not require the participation of the superficial pharyngeal endoderm.
A K Sater; A G Jacobson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  105     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1990-01-29     Completed Date:  1990-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  821-30     Citation Subset:  IM    
Department of Zoology, University of Texas, Austin 78712.
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MeSH Terms
Cell Differentiation*
Embryonic Induction*
Gastrula / physiology*
Heart / embryology*
Xenopus laevis

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