Document Detail


The specification of early hematopoiesis in the mammal.
MedLine Citation:
PMID:  15867578     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: A number of interesting surprises has emerged during the past year in the field of early hematopoietic development. This review highlights recent studies that have challenged the prevailing view of embryonic and fetal hematopoiesis in mammals, with a focus on the mouse as a model system. The authors apologize to the many colleagues whose work could not be cited because of space limitations. RECENT FINDINGS: Advances in our understanding of the embryonic origins of hematopoiesis in mammals and in the regulation of primitive and definitive hematopoietic development are discussed. SUMMARY: The ontological relation between primitive (embryonic) and definitive (fetal and adult) hematopoiesis still holds some mysteries for the biologist. Both technical and conceptual breakthroughs have refined our view of how blood cells form at different stages of development. What we learn from the embryo is not only of fundamental interest but may have future applications in the clinic.
Authors:
Margaret H Baron; Stuart T Fraser
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in hematology     Volume:  12     ISSN:  1065-6251     ISO Abbreviation:  Curr. Opin. Hematol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-03     Completed Date:  2005-11-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9430802     Medline TA:  Curr Opin Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  217-21     Citation Subset:  IM    
Affiliation:
Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA. margaret.baron@mssm.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Lineage / physiology
Embryo, Mammalian / cytology,  physiology*
Erythroid Precursor Cells / physiology
Erythropoiesis / physiology
Hematopoiesis / physiology*
Hematopoietic Stem Cells / cytology,  physiology*
Mice
Yolk Sac / cytology,  embryology
Grant Support
ID/Acronym/Agency:
R01DK2191/DK/NIDDK NIH HHS; R01EB02209/EB/NIBIB NIH HHS; R01HL62248/HL/NHLBI NIH HHS

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