Document Detail


A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis.
MedLine Citation:
PMID:  2512583     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nonradioactive sequence-specific oligonucleotide probes specific for the HLA-DP beta locus have been used in a simple dot-blot format to type samples amplified by the polymerase chain reaction from 44 patients with pauciarticular juvenile rheumatoid arthritis, 32 patients with adult rheumatoid arthritis, and 50 random controls. The sequences of four new DP beta alleles derived from these patients and controls are reported, bringing the total number of alleles identified thus far to 19. The DPB2.1 allele is significantly increased in juvenile rheumatoid arthritis patients over controls; this allele is not increased in patients with adult rheumatoid arthritis. The association of juvenile rheumatoid arthritis with the DPB2.1 allele is independent of linkage with previously defined HLA-D region markers of disease. Analysis of the DPB2.1 sequence shows that it differs from the nonsusceptible DPB4.2 allele by only 1 amino acid at position 69 in the beta 1 domain.
Authors:
A B Begovich; T L Bugawan; B S Nepom; W Klitz; G T Nepom; H A Erlich
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  86     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-01-19     Completed Date:  1990-01-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9489-93     Citation Subset:  IM    
Affiliation:
Department of Human Genetics, Cetus Corporation, Emeryville, CA 94608.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alleles*
Amino Acid Sequence
Arthritis, Juvenile Rheumatoid / genetics*,  immunology
Arthritis, Rheumatoid / genetics*,  immunology
Base Sequence
Exons
Gene Frequency
Genes, MHC Class II
HLA-DP Antigens / genetics*
Haplotypes / genetics,  immunology
Humans
Molecular Sequence Data
Oligonucleotide Probes
Polymerase Chain Reaction
Reference Values
Sequence Homology, Nucleic Acid
Grant Support
ID/Acronym/Agency:
AR37296/AR/NIAMS NIH HHS; AR38883/AR/NIAMS NIH HHS; HD12731/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/HLA-DP Antigens; 0/Oligonucleotide Probes
Comments/Corrections

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