Document Detail


Is specific HIV eradication from the brain possible or needed?
MedLine Citation:
PMID:  23289898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: There is increasing interest in the possibility of eradication of HIV, given the recent case reports. However, it is not clear to what extent brain involvement by HIV poses a challenge to systemic eradication strategies.
AREAS COVERED: This review will outline the mechanisms of HIV latency, the various eradication strategies presently under consideration followed by a discussion of the issue of the frequency and severity of brain involvement by HIV. In those patients with HIV brain disease the challenges will be delineated as well as potential approaches to circumvent or minimise them.
EXPERT OPINION: Eradication of HIV from the brain using specific methodologies is likely only needed in some patients. However, both the identification of such patients and the details of the necessary methodologies require much more research.
Authors:
Bruce J Brew; Lachlan Gray; Sharon Lewin; Melissa Churchill
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-05
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  13     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-11     Completed Date:  2013-07-25     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  403-9     Citation Subset:  IM    
Affiliation:
St Vincent's Hospital, Darlinghurst, NSW, 2010, Australia. B.Brew@UNSW.edu.au
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MeSH Terms
Descriptor/Qualifier:
AIDS Dementia Complex / virology*
Antiviral Agents / therapeutic use*
Brain / virology*
Disease Eradication*
Disease Reservoirs
HIV-1 / physiology*
Humans
Virus Latency*
Chemical
Reg. No./Substance:
0/Antiviral Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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