Document Detail


The species-specific nature of the ototoxicity of dihydrostreptomycin in the patas monkey.
MedLine Citation:
PMID:  2436117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The remarkable susceptibility of the inner ear of the patas monkey (Erythrocebus patas) to the ototoxic action of dihydrostreptomycin (DHSM) (and streptomycin (SM)) is well established in this paper and affords a rare example of a species-specific reaction to a restricted class of compounds within the aminoglycoside group of antibiotics. In a series of experiments, behavioral and morphological observations together provided the following profile of DHSM ototoxicity in the patas monkey: Sudden onset of hearing loss beginning after 7-9 weeks of treatment; Substantial, though often partial, hearing impairment beginning at the high frequencies and progressing with or without continued treatment to the low frequencies; In the inner ear, a corresponding and selective loss of nerve fibers and of outer hair cells, relative to inner hair cells, beginning in the base of the cochlea and proceeding toward the apex; Continued and progressive loss of hearing for several months after cessation of drug treatment; and Non-auditory effects in some animals on the kidney and vestibular system. Results from control experiments confirmed this special relationship between the patas monkey and DHSM: Other nonhuman primates (macaques and vervet monkeys) were essentially unaffected by DHSM; The patas showed no equivalent sensitivity to other aminoglycosides such as kanamycin or to other forms of ototraumatic insult such as intense noise.
Authors:
W C Stebbins; D B Moody; J E Hawkins; L G Johnsson; M A Norat
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurotoxicology     Volume:  8     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  1987  
Date Detail:
Created Date:  1987-05-21     Completed Date:  1987-05-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Auditory Threshold / drug effects
Cercopithecus aethiops
Dihydrostreptomycin Sulfate / toxicity*
Dose-Response Relationship, Drug
Ear, Inner / drug effects,  pathology
Erythrocebus patas
Hearing Disorders / chemically induced*,  pathology
Kanamycin / toxicity
Macaca
Species Specificity*
Streptomycin / therapeutic use,  toxicity
Time Factors
Grant Support
ID/Acronym/Agency:
NS 05065/NS/NINDS NIH HHS; NS 05077/NS/NINDS NIH HHS; NS 05785/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
5490-27-7/Dihydrostreptomycin Sulfate; 57-92-1/Streptomycin; 59-01-8/Kanamycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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