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A specialized team approach to diagnosis and medical versus surgical treatment of infants with congenital hyperinsulinism.
MedLine Citation:
PMID:  21186002     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Hyperinsulinism (HI) is the most common cause of transient and permanent forms of hypoglycemia in infancy. Establishing the correct diagnosis and initiating appropriate therapy without delay is of utmost importance. Once the diagnosis is made and if medical therapy with diazoxide fails, one should assume that the infant has a K(ATP) channel defect and may require surgery. In this case, the infant should be referred to a center that specializes in HI with 18-fluoro L-3,4-dihydroxyphenylalanine positron emission tomography scan. This report describes a center specializing in HI with a team of experts consisting of endocrinologists, nurse practitioners, geneticists, radiologists, pathologists, and a surgeon. It describes the center's paradigm for managing severe HI on the basis of more than 250 cases of HI in the past 10 years, including the diagnosis of HI, medical options, genetics of HI, imaging in HI, the surgical approach to HI, and outcomes.
Authors:
Andrew A Palladino; Charles A Stanley
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in pediatric surgery     Volume:  20     ISSN:  1532-9453     ISO Abbreviation:  Semin. Pediatr. Surg.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2010-12-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216162     Medline TA:  Semin Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-7     Citation Subset:  IM    
Copyright Information:
2011 Elsevier Inc. All rights reserved.
Affiliation:
Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA. palladinoa@email.chop.edu
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