Document Detail


A spatiotemporal profile of visual system activation revealed by current source density analysis in the awake macaque.
MedLine Citation:
PMID:  9823479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the spatiotemporal activation pattern, produced by one visual stimulus, across cerebral cortical regions in awake monkeys. Laminar profiles of postsynaptic potentials and action potentials were indexed with current source density (CSD) and multiunit activity profiles respectively. Locally, we found contrasting activation profiles in dorsal and ventral stream areas. The former, like V1 and V2, exhibit a 'feedforward' profile, with excitation beginning at the depth of Lamina 4, followed by activation of the extragranular laminae. The latter often displayed a multilaminar/columnar profile, with initial responses distributed across the laminae and reflecting modulation rather than excitation; CSD components were accompanied by either no changes or by suppression of action potentials. System-wide, response latencies indicated a large dorsal/ventral stream latency advantage, which generalizes across a wide range of methods. This predicts a specific temporal ordering of dorsal and ventral stream components of visual analysis, as well as specific patterns of dorsal-ventral stream interaction. Our findings support a hierarchical model of cortical organization that combines serial and parallel elements. Critical in such a model is the recognition that processing within a location typically entails multiple temporal components or 'waves' of activity, driven by input conveyed over heterogeneous pathways from the retina.
Authors:
C E Schroeder; A D Mehta; S J Givre
Related Documents :
7808639 - Reflection of the systemic mechanisms of instrumental behavior in the activity of brain...
16448249 - Insect detection of small targets moving in visual clutter.
18333969 - Neuronal correlates of perceptual stability during eye movements.
22467399 - Acute lesions of primary visual cortical areas in adult cats inactivate responses of ne...
7751939 - Visual topography in primate v2: multiple representation across functional stripes.
6616189 - Retinotopic organization of striate and extrastriate visual cortex in the hooded rat.
1975639 - Different voltage-dependent thresholds for inducing long-term depression and long-term ...
17052839 - Are visual stimuli sufficient to evoke motor information? studies with hand primes.
18606019 - Functional magnetic resonance imaging (fmri) changes and saliva production associated w...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cerebral cortex (New York, N.Y. : 1991)     Volume:  8     ISSN:  1047-3211     ISO Abbreviation:  Cereb. Cortex     Publication Date:    1998 Oct-Nov
Date Detail:
Created Date:  1999-02-09     Completed Date:  1999-02-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9110718     Medline TA:  Cereb Cortex     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  575-92     Citation Subset:  IM; S    
Affiliation:
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, New York, USA. schrod@nki.rfmh.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Evoked Potentials, Visual / physiology
Macaca fascicularis
Magnetoencephalography
Male
Photic Stimulation
Reaction Time / physiology*
Space Perception / physiology*
Visual Pathways / physiology*
Grant Support
ID/Acronym/Agency:
MH47939/MH/NIMH NIH HHS; MH55620/MH/NIMH NIH HHS; T32GM7288/GM/NIGMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dynamic cortical networks of verbal and spatial working memory: effects of memory load and task prac...
Next Document:  Concurrent performance of two working memory tasks: potential mechanisms of interference.