Document Detail

A spatiotemporal profile of visual system activation revealed by current source density analysis in the awake macaque.
MedLine Citation:
PMID:  9823479     Owner:  NLM     Status:  MEDLINE    
We investigated the spatiotemporal activation pattern, produced by one visual stimulus, across cerebral cortical regions in awake monkeys. Laminar profiles of postsynaptic potentials and action potentials were indexed with current source density (CSD) and multiunit activity profiles respectively. Locally, we found contrasting activation profiles in dorsal and ventral stream areas. The former, like V1 and V2, exhibit a 'feedforward' profile, with excitation beginning at the depth of Lamina 4, followed by activation of the extragranular laminae. The latter often displayed a multilaminar/columnar profile, with initial responses distributed across the laminae and reflecting modulation rather than excitation; CSD components were accompanied by either no changes or by suppression of action potentials. System-wide, response latencies indicated a large dorsal/ventral stream latency advantage, which generalizes across a wide range of methods. This predicts a specific temporal ordering of dorsal and ventral stream components of visual analysis, as well as specific patterns of dorsal-ventral stream interaction. Our findings support a hierarchical model of cortical organization that combines serial and parallel elements. Critical in such a model is the recognition that processing within a location typically entails multiple temporal components or 'waves' of activity, driven by input conveyed over heterogeneous pathways from the retina.
C E Schroeder; A D Mehta; S J Givre
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cerebral cortex (New York, N.Y. : 1991)     Volume:  8     ISSN:  1047-3211     ISO Abbreviation:  Cereb. Cortex     Publication Date:    1998 Oct-Nov
Date Detail:
Created Date:  1999-02-09     Completed Date:  1999-02-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9110718     Medline TA:  Cereb Cortex     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  575-92     Citation Subset:  IM; S    
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, New York, USA.
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MeSH Terms
Evoked Potentials, Visual / physiology
Macaca fascicularis
Photic Stimulation
Reaction Time / physiology*
Space Perception / physiology*
Visual Pathways / physiology*
Grant Support

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