Document Detail


Mid1/Anillin and the spatial regulation of cytokinesis in fission yeast.
MedLine Citation:
PMID:  22888038     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cell division is a critical and irreversible step in the cell cycle. The strategies that cells follow to regulate the position of the division plane must take into account the global geometry of the cell as well as the position of the genetic material to ensure its accurate segregation into daughter cells of a given cell shape and size. Along the years, research on Schizosaccharomyces pombe, a well-recognized model organism for cell division studies has allowed a detailed molecular understanding of the spatial mechanisms regulating cytokinesis. Division plane position in this unicellular rod-shaped organism, which divides by the assembly and constriction of a medially placed acto-myosin ring, largely depends on the anillin-like protein Mid1. Therefore, the major pathways controlling the position of the division plane converge on Mid1. In this review, we make an overview of the studies that have deciphered how Mid1 localization and scaffolding activities are controlled over the cell cycle to ensure the symmetrical division of fission yeast cells. These studies have revealed new mechanisms generating spatial information based on nuclear shuttling of the division plane factor Mid1 and on the establishment of cortical inhibitory gradients of the cell polarity kinase Pom1. © 2012 Wiley-Blackwell, Inc.
Authors:
Sergio A Rincon; Anne Paoletti
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-6
Journal Detail:
Title:  Cytoskeleton (Hoboken, N.J.)     Volume:  -     ISSN:  1949-3592     ISO Abbreviation:  Cytoskeleton (Hoboken)     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101523844     Medline TA:  Cytoskeleton (Hoboken)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Institut Curie, Centre de recherche,F-75248 PARIS cedex 05; CNRS UMR144,F-75248 PARIS cedex 05.
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