Document Detail


Mid1/anillin and the spatial regulation of cytokinesis in fission yeast.
MedLine Citation:
PMID:  22888038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell division is a critical and irreversible step in the cell cycle. The strategies that cells follow to regulate the position of the division plane must take into account the global geometry of the cell as well as position of the genetic material to ensure its accurate segregation into daughter cells of a given cell shape and size. Along the years, research on Schizosaccharomyces pombe, a well-recognized model organism for cell division studies has allowed a detailed molecular understanding of the spatial mechanisms regulating cytokinesis. Division plane position in this unicellular rod-shaped organism, which divides by the assembly and constriction of a medially placed actomyosin ring, largely depends on the anillin-like protein Mid1. Therefore, the major pathways controlling the position of the division plane converge on Mid1. In this review, we make an overview of the studies that have deciphered how Mid1 localization and scaffolding activities are controlled over the cell cycle to ensure the symmetrical division of fission yeast cells. These studies have revealed new mechanisms generating spatial information based on nuclear shuttling of the division plane factor Mid1 and on the establishment of cortical inhibitory gradients of the cell polarity kinase Pom1.
Authors:
Sergio A Rincon; Anne Paoletti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-08-20
Journal Detail:
Title:  Cytoskeleton (Hoboken, N.J.)     Volume:  69     ISSN:  1949-3592     ISO Abbreviation:  Cytoskeleton (Hoboken)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-23     Completed Date:  2013-03-21     Revised Date:  2014-07-24    
Medline Journal Info:
Nlm Unique ID:  101523844     Medline TA:  Cytoskeleton (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  764-77     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Cell Nucleus / metabolism
Contractile Proteins / chemistry,  metabolism*
Cytokinesis*
Schizosaccharomyces / cytology*,  metabolism*
Schizosaccharomyces pombe Proteins / chemistry,  metabolism*
Signal Transduction
Chemical
Reg. No./Substance:
0/Contractile Proteins; 0/Mid1 protein, S pombe; 0/Schizosaccharomyces pombe Proteins; 0/anillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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