Document Detail


The spatial and mechanical challenges of female meiosis.
MedLine Citation:
PMID:  21774026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent work shows that cytokinesis and other cellular morphogenesis events are tuned by an interplay among biochemical signals, cell shape, and cellular mechanics. In cytokinesis, this includes cross-talk between the cortical cytoskeleton and the mitotic spindle in coordination with cell cycle control, resulting in characteristic changes in cellular morphology and mechanics through metaphase and cytokinesis. The changes in cellular mechanics affect not just overall cell shape, but also mitotic spindle morphology and function. This review will address how these principles apply to oocytes undergoing the asymmetric cell divisions of meiosis I and II. The biochemical signals that regulate cell cycle timing during meiotic maturation and egg activation are crucial for temporal control of meiosis. Spatial control of the meiotic divisions is also important, ensuring that the chromosomes are segregated evenly and that meiotic division is clearly asymmetric, yielding two daughter cells - oocyte and polar body - with enormous volume differences. In contrast to mitotic cells, the oocyte does not undergo overt changes in cell shape with its progression through meiosis, but instead maintains a relatively round morphology with the exception of very localized changes at the time of polar body emission. Placement of the metaphase-I and -II spindles at the oocyte periphery is clearly important for normal polar body emission, although this is likely not the only control element. Here, consideration is given to how cellular mechanics could contribute to successful mammalian female meiosis, ultimately affecting egg quality and competence to form a healthy embryo.
Authors:
Janice P Evans; Douglas N Robinson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-07-19
Journal Detail:
Title:  Molecular reproduction and development     Volume:  78     ISSN:  1098-2795     ISO Abbreviation:  Mol. Reprod. Dev.     Publication Date:    2011 Oct-Nov
Date Detail:
Created Date:  2011-10-18     Completed Date:  2012-03-05     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  8903333     Medline TA:  Mol Reprod Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  769-77     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Affiliation:
Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA. jpevans@jhsph.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics / genetics,  physiology*
Cell Polarity / physiology
Cell Shape / physiology
Female
Humans
Mammals / genetics,  metabolism,  physiology
Meiosis / physiology*
Mitosis / physiology
Models, Biological
Oocytes / cytology*,  metabolism,  physiology*
Polar Bodies / cytology,  physiology
Grant Support
ID/Acronym/Agency:
GM066817/GM/NIGMS NIH HHS; HD045671/HD/NICHD NIH HHS; R01 GM066817-09/GM/NIGMS NIH HHS; R01 HD037696-10/HD/NICHD NIH HHS; R01 HD045671-05/HD/NICHD NIH HHS
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