Document Detail

The spatial distribution of fixed mutations within genes coding for proteins.
MedLine Citation:
PMID:  6317874     Owner:  NLM     Status:  MEDLINE    
We have examined the extensive amino acid sequence data now available for five protein families - the alpha crystallin A chain, myoglobin, alpha and beta hemoglobin, and the cytochromes c - with the goal of estimating the true spatial distribution of base substitutions within genes that code for proteins. In every case the commonly used Poisson density failed to even approximate the experimental pattern of base substitution. For the 87 species of beta hemoglobin examined, for example, the probability that the observed results were from a Poisson process was the minuscule 10(-44). Analogous results were obtained for the other functional families. All the data were reasonably, but not perfectly, described by the negative binomial density. In particular, most of the data were described by one of the very simple limiting forms of this density, the geometric density. The implications of this for evolutionary inference are discussed. It is evident that most estimates of total base substitutions between genes are badly in need of revision.
R Holmquist; M Goodman; T Conroy; J Czelusniak
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of molecular evolution     Volume:  19     ISSN:  0022-2844     ISO Abbreviation:  J. Mol. Evol.     Publication Date:  1983  
Date Detail:
Created Date:  1984-02-24     Completed Date:  1984-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0360051     Medline TA:  J Mol Evol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  437-48     Citation Subset:  IM; S    
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MeSH Terms
Amino Acid Sequence
Codon / genetics
Cytochrome c Group / genetics
Hemoglobins / genetics
Models, Genetic
Myoglobin / genetics
Proteins / genetics*
Reg. No./Substance:
0/Codon; 0/Cytochrome c Group; 0/Hemoglobins; 0/Myoglobin; 0/Proteins

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