| The spatial distribution of fixed mutations within genes coding for proteins. | |
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MedLine Citation:
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PMID: 6317874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have examined the extensive amino acid sequence data now available for five protein families - the alpha crystallin A chain, myoglobin, alpha and beta hemoglobin, and the cytochromes c - with the goal of estimating the true spatial distribution of base substitutions within genes that code for proteins. In every case the commonly used Poisson density failed to even approximate the experimental pattern of base substitution. For the 87 species of beta hemoglobin examined, for example, the probability that the observed results were from a Poisson process was the minuscule 10(-44). Analogous results were obtained for the other functional families. All the data were reasonably, but not perfectly, described by the negative binomial density. In particular, most of the data were described by one of the very simple limiting forms of this density, the geometric density. The implications of this for evolutionary inference are discussed. It is evident that most estimates of total base substitutions between genes are badly in need of revision. |
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Authors:
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R Holmquist; M Goodman; T Conroy; J Czelusniak |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of molecular evolution Volume: 19 ISSN: 0022-2844 ISO Abbreviation: J. Mol. Evol. Publication Date: 1983 |
Date Detail:
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Created Date: 1984-02-24 Completed Date: 1984-02-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0360051 Medline TA: J Mol Evol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 437-48 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Codon / genetics Cytochrome c Group / genetics Genes* Hemoglobins / genetics Humans Models, Genetic Mutation* Myoglobin / genetics Phylogeny* Proteins / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Codon; 0/Cytochrome c Group; 0/Hemoglobins; 0/Myoglobin; 0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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