| The spatial and developmental relationships in the macrophage family. | |
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MedLine Citation:
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PMID: 21677294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A classic study in 1968 proposed that bone marrow-dwelling promonocytes differentiate to monocytes, which then intravasate, circulate, and, on tissue entry, differentiate to sessile macrophages. Since then, understanding of the macrophage family relationship has undergone substantial enhancement and occasional revision. It is currently recognized that in addition to their role in the bone marrow, hematopoietic progenitors circulate and give rise to their descendants in extramedullary niches. Monocytes, of which there are several subsets, are not merely circulating macrophage precursors but participate in the immune response in their own right. Macrophages are highly heterogeneous and, as recent studies indicate, can arise in the absence of a monocyte intermediate. These spatial and developmental relationships reveal a complex interactive network and underscore the importance of context in evaluating biological systems. The observations have significant implications for how we image, target, and treat disease. |
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Authors:
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Filip K Swirski |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 31 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-16 Completed Date: 2011-08-19 Revised Date: 2012-02-28 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1517-22 Citation Subset: IM |
Affiliation:
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Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Bldg, 185 Cambridge St, Boston, MA 02114, USA. fswirski@mgh.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Hematopoiesis Hematopoietic Stem Cells / physiology* Humans Macrophages / physiology* Monocytes / physiology* Signal Transduction Stem Cell Niche |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL095612-02/HL/NHLBI NIH HHS; R01 HL095612-04/HL/NHLBI NIH HHS; R01-HL095612/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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