| The source of cells for allografting. | |
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MedLine Citation:
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PMID: 14652849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peripheral blood is used almost exclusively as the source of hematopoietic cells for autografting, but the best source of cells for allografting is the subject of considerable discussion and debate. Randomized studies comparing unstimulated bone marrow with G-CSF-mobilized peripheral blood in the sibling allogeneic setting have indicated a trend to more chronic graft-versus-host disease in peripheral blood recipients. However, whether the use of G-CSF-mobilized peripheral blood cells leads to more acute graft-versus-host disease is uncertain. Adults undergoing sibling allografting appear to benefit in terms of improved disease-free survival or improved overall survival with the use of G-CSF-mobilized peripheral blood. It is not clear, however, whether these benefits also extend to children or those undergoing matched unrelated transplantation. |
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Authors:
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Stephen Couban; Michael Barnett |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Volume: 9 ISSN: 1083-8791 ISO Abbreviation: Biol. Blood Marrow Transplant. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-07-26 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9600628 Medline TA: Biol Blood Marrow Transplant Country: United States |
Other Details:
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Languages: eng Pagination: 669-73 Citation Subset: IM |
Affiliation:
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Department of Medicine, Queen Elizaberth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada. stephen.couban@cdha.nshealth.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bone Marrow Transplantation
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methods Child Granulocyte Colony Stimulating Factor, Recombinant / therapeutic use Hematopoietic Stem Cell Mobilization / methods Hematopoietic Stem Cells* Humans Transplantation, Homologous / statistics & numerical data* |
| Chemical | |
Reg. No./Substance:
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0/Granulocyte Colony Stimulating Factor, Recombinant |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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