| The sound and the fury: was it all worth it? | |
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MedLine Citation:
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PMID: 18813016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The initial report of coronary heart disease (CHD) results from the trial of menopausal hormone therapy within the Women's Health Initiative precipitated substantial surprise and concern in the epidemiology research community over the apparent differences between the trial results and those of observational studies. What followed was 6 years of discussion and debate, frequently acrimonious, along with intense methodologic and substantive research attempting to reconcile or explain the apparent differences. The results have been an impressive improvement in methods to contrast and combine studies of differing designs, dramatic illustrations of some central epidemiologic principles, insights into likely mechanisms of CHD, and increasing clarity of the public health message about menopausal hormone therapy. |
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Authors:
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Robert N Hoover |
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Publication Detail:
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Type: Comment; Editorial |
Journal Detail:
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Title: Epidemiology (Cambridge, Mass.) Volume: 19 ISSN: 1531-5487 ISO Abbreviation: Epidemiology Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-15 Completed Date: 2009-03-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9009644 Medline TA: Epidemiology Country: United States |
Other Details:
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Languages: eng Pagination: 780-2; discussion 789-93 Citation Subset: IM |
Affiliation:
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Division of Epidemiology and Genetics, Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland 20892, USA. hooverr@mail.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiovascular Diseases
/
etiology,
prevention & control* Data Interpretation, Statistical Estrogen Replacement Therapy / adverse effects* Female Health Surveys Humans Longitudinal Studies Middle Aged Observation / methods* Odds Ratio Randomized Controlled Trials as Topic / methods* Selection Bias Time Factors |
| Comments/Corrections | |
Comment On:
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Epidemiology. 2008 Nov;19(6):766-79
[PMID:
18854702
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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