Document Detail

The sound and the fury: was it all worth it?
MedLine Citation:
PMID:  18813016     Owner:  NLM     Status:  MEDLINE    
The initial report of coronary heart disease (CHD) results from the trial of menopausal hormone therapy within the Women's Health Initiative precipitated substantial surprise and concern in the epidemiology research community over the apparent differences between the trial results and those of observational studies. What followed was 6 years of discussion and debate, frequently acrimonious, along with intense methodologic and substantive research attempting to reconcile or explain the apparent differences. The results have been an impressive improvement in methods to contrast and combine studies of differing designs, dramatic illustrations of some central epidemiologic principles, insights into likely mechanisms of CHD, and increasing clarity of the public health message about menopausal hormone therapy.
Robert N Hoover
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Publication Detail:
Type:  Comment; Editorial    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  19     ISSN:  1531-5487     ISO Abbreviation:  Epidemiology     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-15     Completed Date:  2009-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  780-2; discussion 789-93     Citation Subset:  IM    
Division of Epidemiology and Genetics, Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland 20892, USA.
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MeSH Terms
Cardiovascular Diseases / etiology,  prevention & control*
Data Interpretation, Statistical
Estrogen Replacement Therapy / adverse effects*
Health Surveys
Longitudinal Studies
Middle Aged
Observation / methods*
Odds Ratio
Randomized Controlled Trials as Topic / methods*
Selection Bias
Time Factors
Comment On:
Epidemiology. 2008 Nov;19(6):766-79   [PMID:  18854702 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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