| The sonodynamic antitumor effect of methylene blue on sarcoma180 cells in vitro. | |
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MedLine Citation:
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PMID: 19528509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Sonodynamic therapy (SDT) is a promising methodology for cancer treatment. Methylene blue (MB) is a phenothiazine dye that is widely used in clinical practice and can be administered intravenously. MATERIALS AND METHODS: The sonodynamic antitumor effect of 1, 10 and 100 microM MB on sarcoma180 (S180) cells was investigated in vitro. RESULTS: After ultrasound (US) exposure at 0.24 W/cm(2) for 30 seconds, survival rates of S180 cells in the presence of 10 and 100 microM MB were significantly lower than that of the control group. These effects were significantly inhibited by the addition of D-mannitol, but not by L-histidine or superoxide dismutase. Microvilli loss and blebbing on the surface of S180 cells were observed in the presence of 100 muM MB after US exposure. CONCLUSION: MB has a sonodynamic antitumor effect on S180 cells in vitro and the hydroxyl radical appears to be the principal mediator of this effect. |
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Authors:
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Chiyo Komori; Kyoji Okada; Koichi Kawamura; Shuichi Chida; Toshio Suzuki |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 29 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-16 Completed Date: 2009-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 2411-5 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Science, Akita University Hospital, Akita 010-8543, Japan. k-chiyo@hos.akita-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Survival / drug effects Enzyme Inhibitors / pharmacology* Male Mannitol / pharmacology Methylene Blue / pharmacology* Mice Mice, Inbred ICR Oxygen / metabolism Sarcoma 180 / therapy* Sweetening Agents / pharmacology Tumor Cells, Cultured Ultrasonic Therapy* |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Sweetening Agents; 61-73-4/Methylene Blue; 69-65-8/Mannitol; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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