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The somatotropic axis in postmenopausal women during six month of transdermal continuous 17beta-estradiol administration combined with oral medroxyprogesterone.
MedLine Citation:
PMID:  21721462     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
AIM: The evaluation of the influence of continuous transdermal estradiol supplementation combined with oral medroxyprogesterone on the somatotropic axis in postmenopausal women.
MATERIAL AND METHODS: 25 women completed the study Group A--13 women received transdermal 17beta-estradiol (Oesclim 50 - Fournier-Solvay) combined with oral 5 mg daily medroxyprogesterone (Gestomikron - Adamed). Group B--12 women without treatment. Basic plasma FSH, estradiol, glucose, insulin, SHBG, hGH, total and free IGF-I, IGFBP-1 as well as IGFBP-3 were measured initially and at the 12th and 24th week of the study.
RESULTS: The mean plasma FSH level was reduced and mean plasma estradiol level was increased in group A during estradiol supplementation. Mean plasma level of free IGF-I and free to total IGF-I ratio were increased in group A during 24 weeks of hormone therapy. In the control group (group B) there was the significant increase in mean plasma IGFBP-3 level. Other parameters showed no significant changes in the control group.
CONCLUSION: The administration of transdermal 17beta-estradiol combined with oral medroxyprogesterone increases the IGF-I bioavailability. However this influence do not exceed the physiologial level of IGF-I bioavailability.
Authors:
Tomasz Milewicz; Józef Krzysiek; Iwona Rogatko; Krystyna Sztefko; Ewa Stochmal; Alicja Hubalewska-Dydejczyk; Robert Jach; Stanisław Radowicki
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ginekologia polska     Volume:  82     ISSN:  0017-0011     ISO Abbreviation:  Ginekol. Pol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-07-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374641     Medline TA:  Ginekol Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  254-8     Citation Subset:  IM    
Affiliation:
Klinika Endokrynologii Ginekologicznej, Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie, Polska. milewicz@interia.eu
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