| The somatotropic axis in postmenopausal women during six month of transdermal continuous 17beta-estradiol administration combined with oral medroxyprogesterone. | |
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MedLine Citation:
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PMID: 21721462 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIM: The evaluation of the influence of continuous transdermal estradiol supplementation combined with oral medroxyprogesterone on the somatotropic axis in postmenopausal women. MATERIAL AND METHODS: 25 women completed the study Group A--13 women received transdermal 17beta-estradiol (Oesclim 50 - Fournier-Solvay) combined with oral 5 mg daily medroxyprogesterone (Gestomikron - Adamed). Group B--12 women without treatment. Basic plasma FSH, estradiol, glucose, insulin, SHBG, hGH, total and free IGF-I, IGFBP-1 as well as IGFBP-3 were measured initially and at the 12th and 24th week of the study. RESULTS: The mean plasma FSH level was reduced and mean plasma estradiol level was increased in group A during estradiol supplementation. Mean plasma level of free IGF-I and free to total IGF-I ratio were increased in group A during 24 weeks of hormone therapy. In the control group (group B) there was the significant increase in mean plasma IGFBP-3 level. Other parameters showed no significant changes in the control group. CONCLUSION: The administration of transdermal 17beta-estradiol combined with oral medroxyprogesterone increases the IGF-I bioavailability. However this influence do not exceed the physiologial level of IGF-I bioavailability. |
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Authors:
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Tomasz Milewicz; Józef Krzysiek; Iwona Rogatko; Krystyna Sztefko; Ewa Stochmal; Alicja Hubalewska-Dydejczyk; Robert Jach; Stanisław Radowicki |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ginekologia polska Volume: 82 ISSN: 0017-0011 ISO Abbreviation: Ginekol. Pol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-07-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374641 Medline TA: Ginekol Pol Country: Poland |
Other Details:
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Languages: eng Pagination: 254-8 Citation Subset: IM |
Affiliation:
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Klinika Endokrynologii Ginekologicznej, Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie, Polska. milewicz@interia.eu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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