| The small-eye mutation results in abnormalities in the lateral cortical migratory stream. | |
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MedLine Citation:
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PMID: 9733944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mice with homozygous mutations of the Pax-6 gene exhibit a constellation of developmental problems including the absence of eyes and nasal cavities and problems in the movement of neuroblasts out of the germinal epithelium. In this paper, we demonstrate further disturbances in neuronal migration. Normally, cells produced along the lateral ventricles move laterally across the pallium, ultimately coming to reside in the lateral neocortex and primary olfactory cortex. In mutant animals, these cells continue to migrate to the pial surface of the brain. |
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Authors:
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P C Brunjes; M Fisher; R Grainger |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research. Developmental brain research Volume: 110 ISSN: 0165-3806 ISO Abbreviation: Brain Res. Dev. Brain Res. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-11-16 Completed Date: 1998-11-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8908639 Medline TA: Brain Res Dev Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 121-5 Citation Subset: IM |
Copyright Information:
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Copyright 1998 Elsevier Science B. V. |
Affiliation:
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Department of Psychology, 102 Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA. brunjes@virginia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Movement Cerebral Cortex / abnormalities, embryology*, pathology Cerebral Ventricles / abnormalities, embryology*, pathology DNA-Binding Proteins / genetics* Eye Abnormalities / genetics Eye Proteins / genetics* Homeodomain Proteins* Homozygote Mice Mice, Neurologic Mutants Mutation* Neurons / pathology, physiology* Nose / abnormalities Paired Box Transcription Factors Prosencephalon / abnormalities, embryology*, pathology Repressor Proteins |
| Grant Support | |
ID/Acronym/Agency:
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DC 2400/DC/NIDCD NIH HHS; EY06675/EY/NEI NIH HHS; EY10283/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Eye Proteins; 0/Homeodomain Proteins; 0/PAX6 protein; 0/Paired Box Transcription Factors; 0/Repressor Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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