Document Detail

The small SLC43 family: facilitator system l amino acid transporters and the orphan EEG1.
MedLine Citation:
PMID:  23268354     Owner:  NLM     Status:  MEDLINE    
The SLC43 family is composed of only three genes coding for the plasma membrane facilitator system l amino acid transporters LAT3 (SLC43A1; TC 2.A.1.44.1) and LAT4 (SLC43A2; TC 2.A.1.44.2), and the orphan protein EEG1 (SLC43A3; TC 2.A.1.44.3). Besides the known mechanism of transport of LAT3 and LAT4, their physiological roles still remain quite obscure. Morphants suggested a role of LAT3 in renal podocyte development in zebrafish. Expression in liver and skeletal muscle, and up-regulation by starvation suggest a role of LAT3 in the flux of branched-chain amino acids (BCAAs) from liver and skeletal muscle to the bloodstream. Finally, LAT3 is up-regulated in androgen-dependent cancers, suggesting a role in mTORC1 signaling in this type of tumors. In addition, LAT4 might contribute to the transfer of BCAAs from mother to fetus. Unfortunately, the EEG1 mouse model (EEG1(Y221∗)) described here has not yet offered a clue to the physiological role of this orphan protein.
Susanna Bodoy; Dimitrios Fotiadis; Claudia Stoeger; Yoshikatsu Kanai; Manuel Palacín
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-12-23
Journal Detail:
Title:  Molecular aspects of medicine     Volume:  34     ISSN:  1872-9452     ISO Abbreviation:  Mol. Aspects Med.     Publication Date:    2013 Apr-Jun
Date Detail:
Created Date:  2013-03-19     Completed Date:  2013-09-09     Revised Date:  2013-09-30    
Medline Journal Info:
Nlm Unique ID:  7603128     Medline TA:  Mol Aspects Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  638-45     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Institute for Research in Biomedicine (IRB Barcelona), Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, and Centro de Investigación Biomedica en Red de Enfermedades Raras, E-08028 Barcelona, Spain.
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MeSH Terms
Amino Acid Transport System y+L / genetics*,  metabolism,  physiology*
Amino Acid Transport Systems, Basic / metabolism
Amino Acids / metabolism*
Blotting, Northern
Liver / metabolism
Models, Molecular*
Multigene Family / genetics*
Multiprotein Complexes / metabolism
Muscle, Skeletal / metabolism
Neoplasm Proteins / genetics*,  metabolism,  physiology*
Podocytes / metabolism
TOR Serine-Threonine Kinases / metabolism
Reg. No./Substance:
0/Amino Acid Transport System y+L; 0/Amino Acid Transport Systems, Basic; 0/Amino Acids; 0/Multiprotein Complexes; 0/Neoplasm Proteins; 0/SLC43A1 protein, human; 0/SLC7A6 protein, human; 0/mechanistic target of rapamycin complex 1; EC Serine-Threonine Kinases

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