Document Detail


The small SLC43 family: facilitator system l amino acid transporters and the orphan EEG1.
MedLine Citation:
PMID:  23268354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The SLC43 family is composed of only three genes coding for the plasma membrane facilitator system l amino acid transporters LAT3 (SLC43A1; TC 2.A.1.44.1) and LAT4 (SLC43A2; TC 2.A.1.44.2), and the orphan protein EEG1 (SLC43A3; TC 2.A.1.44.3). Besides the known mechanism of transport of LAT3 and LAT4, their physiological roles still remain quite obscure. Morphants suggested a role of LAT3 in renal podocyte development in zebrafish. Expression in liver and skeletal muscle, and up-regulation by starvation suggest a role of LAT3 in the flux of branched-chain amino acids (BCAAs) from liver and skeletal muscle to the bloodstream. Finally, LAT3 is up-regulated in androgen-dependent cancers, suggesting a role in mTORC1 signaling in this type of tumors. In addition, LAT4 might contribute to the transfer of BCAAs from mother to fetus. Unfortunately, the EEG1 mouse model (EEG1(Y221∗)) described here has not yet offered a clue to the physiological role of this orphan protein.
Authors:
Susanna Bodoy; Dimitrios Fotiadis; Claudia Stoeger; Yoshikatsu Kanai; Manuel Palacín
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-12-23
Journal Detail:
Title:  Molecular aspects of medicine     Volume:  34     ISSN:  1872-9452     ISO Abbreviation:  Mol. Aspects Med.     Publication Date:    2013 Apr-Jun
Date Detail:
Created Date:  2013-03-19     Completed Date:  2013-09-09     Revised Date:  2013-09-30    
Medline Journal Info:
Nlm Unique ID:  7603128     Medline TA:  Mol Aspects Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  638-45     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Institute for Research in Biomedicine (IRB Barcelona), Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, and Centro de Investigación Biomedica en Red de Enfermedades Raras, E-08028 Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Transport System y+L / genetics*,  metabolism,  physiology*
Amino Acid Transport Systems, Basic / metabolism
Amino Acids / metabolism*
Blotting, Northern
Humans
Liver / metabolism
Models, Molecular*
Multigene Family / genetics*
Multiprotein Complexes / metabolism
Muscle, Skeletal / metabolism
Neoplasm Proteins / genetics*,  metabolism,  physiology*
Podocytes / metabolism
TOR Serine-Threonine Kinases / metabolism
Chemical
Reg. No./Substance:
0/Amino Acid Transport System y+L; 0/Amino Acid Transport Systems, Basic; 0/Amino Acids; 0/Multiprotein Complexes; 0/Neoplasm Proteins; 0/SLC43A1 protein, human; 0/SLC7A6 protein, human; 0/mechanistic target of rapamycin complex 1; EC 2.7.1.1/TOR Serine-Threonine Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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