| The small RNA expression profile of the developing murine urinary and reproductive systems. | |
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MedLine Citation:
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PMID: 20933514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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microRNAs (miRNAs) are small non-coding RNAs with fundamental roles in the regulation of gene expression. miRNAs assemble with Argonaute (Ago) proteins to miRNA-protein complexes (miRNPs), which interact with distinct binding sites on mRNAs and regulate gene expression. Specific miRNAs are key regulators of tissue and organ development and it has been shown in mammals that miRNAs are also involved in the pathogenesis of many diseases including cancer. Here, we have characterized the miRNA expression profile of the developing murine genitourinary system. Using a computational approach, we have identified several miRNAs that are specific for the analyzed tissues or the developmental stage. Our comprehensive miRNA expression atlas of the developing genitourinary system forms an invaluable basis for further functional in vivo studies. |
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Authors:
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Ana Laura Gutierrez Aguilar; Robert Piskol; Michaela Beitzinger; Jia Yun Zhu; Dagmar Kruspe; Attila Aszodi; Markus Moser; Christoph Englert; Gunter Meister |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-08 |
Journal Detail:
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Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 4426-34 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Laboratory of RNA Biology, Max-Planck-Institute of Biochemistry, Martinsried, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Cluster Analysis Gene Expression Profiling* Gene Expression Regulation, Developmental Humans Mice MicroRNAs / genetics* Organ Specificity Polymerase Chain Reaction Reproducibility of Results Urogenital System / growth & development*, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/MicroRNAs |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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