Document Detail

The slowing of gastric emptying by four strong acids and three weak acids.
MedLine Citation:
PMID:  5037069     Owner:  NLM     Status:  MEDLINE    
1. Test meals of 750 ml. water containing a range of concentrations of hydrochloric, nitric, sulphuric, cyclamic (cyclohexylsulphamic), tartaric, L-ascorbic and citric acids were instilled into the stomachs of sixteen healthy subjects.2. The greater the concentration of an acid in the instilled meal, the greater was the volume of meal recovered after a fixed interval.3. For the weak acids, tartaric, ascorbic and citric, the concentrations which gave a recovery of 450 ml., out of the 750 ml. instilled, increased with increase in the molecular weight of the acid.4. For the strong acids, hydrochloric, nitric, sulphuric and cyclamic, the concentrations which gave a recovery of 450 ml., out of the 750 ml. instilled, were approximately equal. These concentrations were less than those for weak acids.5. The strong acids with high molecular weights were slightly more effective in slowing gastric emptying than were those with low molecular weights.6. The approximate equality of effectiveness of nitric, sulphuric and cyclamic acids to hydrochloric acid is attributed to the presence of chloride ion in the duodenal contents. Thus all the strong acids instilled produce an environment of hydrochloric acid around the receptor.7. A model for a duodenal receptor responding to acids is proposed.
J N Hunt; M T Knox
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  222     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1972 Apr 
Date Detail:
Created Date:  1972-08-22     Completed Date:  1972-08-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  187-208     Citation Subset:  IM    
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MeSH Terms
Acetic Acids / pharmacology
Acids / pharmacology*
Ascorbic Acid / pharmacology
Butyrates / pharmacology
Caproates / pharmacology
Chemoreceptor Cells / physiology
Chlorides / physiology
Citrates / pharmacology
Cyclamates / pharmacology
Depression, Chemical
Duodenum / drug effects
Gastrointestinal Motility / drug effects*
Hydrochloric Acid / pharmacology
Lactates / pharmacology
Models, Biological
Models, Chemical
Molecular Weight
Nitrates / pharmacology
Phosphoric Acids / pharmacology
Propionates / pharmacology
Stomach / drug effects*
Sulfuric Acids / pharmacology
Tartrates / pharmacology
Reg. No./Substance:
0/Acetic Acids; 0/Acids; 0/Butyrates; 0/Caproates; 0/Chlorides; 0/Citrates; 0/Cyclamates; 0/Lactates; 0/Nitrates; 0/Phosphoric Acids; 0/Propionates; 0/Sulfuric Acids; 0/Tartrates; 50-81-7/Ascorbic Acid; 7647-01-0/Hydrochloric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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