Document Detail


A slit in podocyte death.
MedLine Citation:
PMID:  18673230     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent advances have identified the podocyte as a key target in glomerular injury. The podocyte is a highly specialized cell which is responsible for the glomerular permselectivity for proteins in the kidney. Podocyte injury or loss leads to proteinuria. Apoptosis has been shown to contribute to renal cell loss, including loss of podocytes. The most striking feature of the podocyte is its ability to form intricate specialized cell junctions, the slit diaphragm. Slit diaphragm proteins play an important role in podocyte biology, protein permselectivity, cell signalling and disease. This review focuses on recent advances on the understanding of podocyte survival regulation, its relationship to slit diaphragm structure and function, and how this knowledge may affect our therapeutic approach to proteinuric kidney disease.
Authors:
Juan Antonio Moreno; Maria Dolores Sanchez-Niño; Ana Belen Sanz; Markus Lassila; Harry Holthofer; Luis Miguel Blanco-Colio; Jesus Egido; Marta Ruiz-Ortega; Alberto Ortiz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current medicinal chemistry     Volume:  15     ISSN:  0929-8673     ISO Abbreviation:  Curr. Med. Chem.     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-04     Completed Date:  2008-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1645-54     Citation Subset:  IM    
Affiliation:
Renal and Vascular Research Laboratory, Fundación Jiménez Díaz, Universidad Autónoma, de Madrid and IRSIN, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Death / drug effects
Disease Susceptibility
Humans
Kidney Diseases / drug therapy,  metabolism,  pathology
Pharmaceutical Preparations / chemistry
Podocytes / cytology*,  drug effects
Chemical
Reg. No./Substance:
0/Pharmaceutical Preparations

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