| A slit in podocyte death. | |
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MedLine Citation:
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PMID: 18673230 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent advances have identified the podocyte as a key target in glomerular injury. The podocyte is a highly specialized cell which is responsible for the glomerular permselectivity for proteins in the kidney. Podocyte injury or loss leads to proteinuria. Apoptosis has been shown to contribute to renal cell loss, including loss of podocytes. The most striking feature of the podocyte is its ability to form intricate specialized cell junctions, the slit diaphragm. Slit diaphragm proteins play an important role in podocyte biology, protein permselectivity, cell signalling and disease. This review focuses on recent advances on the understanding of podocyte survival regulation, its relationship to slit diaphragm structure and function, and how this knowledge may affect our therapeutic approach to proteinuric kidney disease. |
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Authors:
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Juan Antonio Moreno; Maria Dolores Sanchez-Niño; Ana Belen Sanz; Markus Lassila; Harry Holthofer; Luis Miguel Blanco-Colio; Jesus Egido; Marta Ruiz-Ortega; Alberto Ortiz |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current medicinal chemistry Volume: 15 ISSN: 0929-8673 ISO Abbreviation: Curr. Med. Chem. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-08-04 Completed Date: 2008-09-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440157 Medline TA: Curr Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1645-54 Citation Subset: IM |
Affiliation:
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Renal and Vascular Research Laboratory, Fundación Jiménez Díaz, Universidad Autónoma, de Madrid and IRSIN, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Death / drug effects Disease Susceptibility Humans Kidney Diseases / drug therapy, metabolism, pathology Pharmaceutical Preparations / chemistry Podocytes / cytology*, drug effects |
| Chemical | |
Reg. No./Substance:
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0/Pharmaceutical Preparations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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