Document Detail


The skinny on Slug.
MedLine Citation:
PMID:  20721976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The zinc finger transcription factor Slug (Snai2) serves a wide variety of functions in the epidermis, with roles in skin development, hair growth, wound healing, skin cancer, and sunburn. Slug is expressed in basal keratinocytes and hair follicles where it is important in maintaining epidermal homeostasis. Slug also helps coordinate the skin response to exogenous stimuli. Slug is rapidly induced by a variety of growth factors and injurious agents and Slug controls, directly or indirectly, a variety of keratinocyte responses, including changes in differentiation, adhesion, motility, and production of inflammatory mediators. Slug thus modulates the interactions of the keratinocyte with its environment and with surrounding cells. The function of Slug in the epidermis appears to be distinct from that of the closely related Snail transcription factor.
Authors:
Stephanie H Shirley; Laurie G Hudson; Jing He; Donna F Kusewitt
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Molecular carcinogenesis     Volume:  49     ISSN:  1098-2744     ISO Abbreviation:  Mol. Carcinog.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-22     Completed Date:  2010-10-20     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8811105     Medline TA:  Mol Carcinog     Country:  United States    
Other Details:
Languages:  eng     Pagination:  851-61     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley-Liss, Inc.
Affiliation:
Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Cell Movement
Epidermis / metabolism
Keratinocytes / metabolism*,  physiology*
Mice
Transcription Factors / physiology*
Wound Healing / physiology
Grant Support
ID/Acronym/Agency:
P30 CA016058/CA/NCI NIH HHS; P30 CA16672/CA/NCI NIH HHS; P30 ES007784/ES/NIEHS NIH HHS; R01 CA089216/CA/NCI NIH HHS; R01 CA089216/CA/NCI NIH HHS; R01 GM079381/GM/NIGMS NIH HHS; R21AR054361/AR/NIAMS NIH HHS; T32 CA09480/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Transcription Factors; 0/snail family transcription factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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