Document Detail


The skinny on fat: lipolysis and fatty acid utilization in adipocytes.
MedLine Citation:
PMID:  19796963     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipolysis for the provision of fatty acids (FA) for other organs during times of energy demand occurs uniquely in white adipose tissue (WAT). Recent findings have identified a bona fide TAG hydrolase and the major adipose phospholipase A(2), AdPLA. By controlling PGE(2) levels, AdPLA dominantly regulates lipolysis in an autocrine/paracrine manner. Moreover, recent findings demonstrate that, surprisingly, increasing lipolysis in adipose tissue does not necessarily increase serum FA levels, which are usually correlated with insulin resistance. Rather, increasing lipolysis in adipose tissue causes a shift within adipocytes towards increased FA utilization and energy expenditure and thus protects against obesity. Here, we discuss the regulation of lipolysis and its effects on FA utilization within WAT and on insulin resistance.
Authors:
Maryam Ahmadian; Robin E Duncan; Hei Sook Sul
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-09-30
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  20     ISSN:  1879-3061     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-20     Completed Date:  2010-01-13     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  424-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipocytes / metabolism*
Adipose Tissue / metabolism
Animals
Energy Metabolism
Fatty Acids / metabolism*
Humans
Insulin Resistance / physiology
Lipolysis / physiology*
Models, Biological
Grant Support
ID/Acronym/Agency:
DK75882/DK/NIDDK NIH HHS; R01 DK050828/DK/NIDDK NIH HHS; R01 DK050828-12/DK/NIDDK NIH HHS; R01 DK075682/DK/NIDDK NIH HHS; R01 DK075682-04/DK/NIDDK NIH HHS; R01 DK081098/DK/NIDDK NIH HHS; R01 DK081098-02/DK/NIDDK NIH HHS; R01 DK093928/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids
Comments/Corrections

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