Document Detail


The skin injury induced by high energy dose of ultraviolet in hairless descendants of Mexican hairless dogs.
MedLine Citation:
PMID:  9151127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Histopathological changes in the dorsal skin of hairless descendants of Mexican hairless dogs (MHDs) exposed to artificial irradiation with high energy dose (180 kJ/m2) of ultraviolet (UV) rays (UVA + B) were investigated. Macroscopically, erythema and edema were observed in the irradiated skin at 1 day after irradiation (DAI), and blister formation occurred except one dog at 2 DAI. Erythema almost disappeared at 5 DAI, and at 6 DAI, the skin recovered to almost normal state. Light microscopically, sunburn cells were observed at 1 DAI. Then intercellular edema and blister formation in the epidermis and dermal edema were evident at 2 and 3 DAI. At 6 DAI, the skin showed almost normal features except for slight epidermal thickening, but melanin granules, which were distributed in almost the whole length of the epidermis before UV irradiation, were detected only in cells which seemed to be melanocytes except one dog. Dihydroxyphenylalanine (DOPA)-positive melanocytes almost disappeared at 1 and 2 DAI, and at 6 DAI, the number of DOPA-positive melanocytes increased over the level before UV irradiation. The ultrastructural features of melanocytes were characterized by vacuolated cytoplasm, decreased melanosomes, irregular-shaped nuclei and shortened dendrites at 1 DAI, and returned to normal at 6 DAI. These findings of melanocytes reflect the severity of the skin injury and support weak suntan reaction in this case. In conclusion, severe form of UV-induced skin injury seen in humans could be reproduced in hairless descendants of MHDs exposed to high energy dose of artificial UVA + B.
Authors:
Y Ishii; T Kimura; S Itagaki; K Doi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histology and histopathology     Volume:  12     ISSN:  0213-3911     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-17     Completed Date:  1997-07-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  383-9     Citation Subset:  IM    
Affiliation:
Department of Biomedical Science, Faculty of Agriculture, University of Tokyo, Bunkyo-ku, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blister / pathology
Dihydroxyphenylalanine / metabolism
Dogs
Edema / pathology
Erythema / pathology
Histocytochemistry
Keratinocytes / radiation effects,  ultrastructure
Male
Melanocytes / metabolism,  radiation effects,  ultrastructure
Microscopy, Electron
Radiation Injuries, Experimental / pathology*
Skin / pathology*,  ultrastructure
Sunburn / pathology
Ultraviolet Rays / adverse effects*
Chemical
Reg. No./Substance:
63-84-3/Dihydroxyphenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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