| Is skin closure with cyanoacrylate glue effective for the prevention of sternal wound infections? | |
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MedLine Citation:
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PMID: 20150191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed whether cyanoacrylate glue was effective at preventing wound infection following sternotomy incision. Altogether more than 108 papers were found using the reported search, of which seven represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. We conclude that applying cyanoacrylate glue to a sternal wound has superior outcomes in terms of infection rates, both if applied preoperatively (decreasing from 10.8% to 2.7% or 7.8% to 1.1%, according to two studies) and postoperatively (4.9%-2.1%). This trend is true of both deep surgical site infections (0.6%-0%) and superficial site infections (4.3%-2.1%). Furthermore, in patients who had developed mediastinitis following cardiac surgery rates of recurrent sternal detachment and osteomyelitis were significantly reduced in cases where sealant was applied compared to controls (35.3% vs. 0%). In all studies examining hospital stay, duration was reduced in cases where cyanoacrylate glue was used, both in patients treated for recurrent mediastinitis (24.06 vs. 14.16 days) and those with uncomplicated recovery following cardiac surgery (13 vs. 9 days). In addition, two studies examining the use of cyanoacrylate glue to secure the sternum in complicated cases of recurrent detachment report success rates of 86% and 100%. |
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Authors:
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Anthony Chambers; Marco Scarci |
Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2010-02-11 |
Journal Detail:
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Title: Interactive cardiovascular and thoracic surgery Volume: 10 ISSN: 1569-9285 ISO Abbreviation: Interact Cardiovasc Thorac Surg Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-08-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101158399 Medline TA: Interact Cardiovasc Thorac Surg Country: England |
Other Details:
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Languages: eng Pagination: 793-6 Citation Subset: IM |
Copyright Information:
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2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved. |
Affiliation:
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Brighton and Sussex Medical School, University of Sussex, Brighton, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Artery Bypass / adverse effects, methods* Coronary Stenosis / complications, radiography, surgery Cyanoacrylates / pharmacology* Diabetes Mellitus, Type 2 / complications, diagnosis Evidence-Based Medicine Female Humans Hypercholesterolemia / complications, diagnosis Hypertension / complications, diagnosis Risk Assessment Skin / surgery Sternotomy / adverse effects*, methods Surgical Wound Infection / prevention & control* Suture Techniques Tensile Strength Tissue Adhesives / pharmacology* Treatment Outcome Wound Healing / physiology |
| Chemical | |
Reg. No./Substance:
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0/Cyanoacrylates; 0/Tissue Adhesives |
| Comments/Corrections | |
Comment In:
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Interact Cardiovasc Thorac Surg. 2010 May;10(5):796
[PMID:
20403990
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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