Document Detail

The skin as interface in the transmission of arthropod-borne pathogens.
MedLine Citation:
PMID:  17490407     Owner:  NLM     Status:  MEDLINE    
Animal skin separates the inner world of the body from the largely hostile outside world and is actively involved in the defence against microbes. However, the skin is no perfect defence barrier and many microorganisms have managed to live on or within the skin as harmless passengers or as disease-causing pathogens. Microbes have evolved numerous strategies that allow them to gain access to the layers underneath the epidermis where they either multiply within the dermis or move to distant destinations within the body for replication. A number of viruses, bacteria and parasites use arthropod vectors, like ticks or mosquitoes, to deliver them into the dermis while taking their blood meal. Within the dermis, successful pathogens subvert the function of a variety of skin resident cells or cells of the innate immune system that rush to the site of infection. In this review several interactions with cells of the skin by medically relevant vector-borne pathogens are discussed to highlight the different ways in which these pathogens have come to survive within the skin and to usurp the defence mechanisms of the host for their own ends.
Freddy Frischknecht
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-05-08
Journal Detail:
Title:  Cellular microbiology     Volume:  9     ISSN:  1462-5814     ISO Abbreviation:  Cell. Microbiol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-20     Completed Date:  2007-08-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100883691     Medline TA:  Cell Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1630-40     Citation Subset:  IM    
Department of Parasitology, Hygiene Institute, Heidelberg University School of Medicine, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.
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MeSH Terms
Arthropod Vectors* / microbiology,  parasitology,  virology
Bacteria / pathogenicity
Bacterial Infections / microbiology,  transmission*
Child, Preschool
Host-Parasite Interactions
Parasites / physiology
Parasitic Diseases / parasitology,  transmission
Skin* / microbiology,  parasitology,  virology
Virus Diseases / transmission*,  virology

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