Document Detail

The skin POMC system (SPS). Leads and lessons from the hair follicle.
MedLine Citation:
PMID:  10816666     Owner:  NLM     Status:  MEDLINE    
Human and murine skin are prominent extrapituitary sources and targets for POMC products. The expression of, for example, ACTH, alpha-MSH, beta-endorphin, and MC-1-receptors fluctuates during synchronized hair follicle cycling in C57BL/6 mice. Since hair growth can be induced by ACTH injections in mice and mink, and since high doses of MSH peptides modulate epidermal and/or follicle keratinocyte proliferation in murine skin organ culture, some POMC products may operate as locally generated growth modulators, in addition to their roles in cutaneous pigment and immunobiology. Intrafollicularly generated ACTH and alpha-MSH as well as their cognate receptors may assist in the maintenance of the peculiar immune privilege of the anagen hair bulb. Possibly, they are also involved in the development of the follicle pigmentary unit, with whose generation their expression coincides. Given that murine skin also expresses (in a hair-cycle-dependent way) CRH and CRH-R, which control pituitary POMC expression and in view of the fact that CRH arrests follicles in telogen, this suggests the existence of a local skin POMC system (SPS). This may be an integral component of cutaneous stress response-systems, and may most instructively be studied using the murine hair cycle as a model.
R Paus; V A Botchkarev; N V Botchkareva; L Mecklenburg; T Luger; A Slominski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  885     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-06-02     Completed Date:  2000-06-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  350-63     Citation Subset:  IM    
Department of Dermatology, Charité, Humboldt-University, Berlin, Germany.
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MeSH Terms
Adrenocorticotropic Hormone / physiology
Hair Follicle / physiology*
Mice, Inbred C57BL
Models, Biological
Pro-Opiomelanocortin / physiology*
Receptors, Corticotropin / physiology
Receptors, Melanocortin
Skin Physiological Phenomena*
alpha-MSH / physiology
beta-Endorphin / physiology
Reg. No./Substance:
0/Receptors, Corticotropin; 0/Receptors, Melanocortin; 581-05-5/alpha-MSH; 60617-12-1/beta-Endorphin; 66796-54-1/Pro-Opiomelanocortin; 9002-60-2/Adrenocorticotropic Hormone

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