Document Detail

The size and shape of particulate polyethylene wear debris in total joint replacements.
MedLine Citation:
PMID:  9141886     Owner:  NLM     Status:  MEDLINE    
Osteolysis induced by wear particles has been recognized as one of the major causes of long-term failure in total joint replacements. However, little is currently known about the exact nature of particles, as the particles are too small to be characterized by light microscopy. In this study, ultra-high molecular weight polyethylene (UHMWPE) particles retrieved from ten cases (six cemented and four uncemented) for Freeman type conforming tibiofemoral total knee replacements (TKRs), three Charnley total hip replacements (THRs) and five Imperial College/London Hospital double cup surface hip replacements for aseptic loosening were extracted using a high-performance method with ultracentrifugation and characterized by scanning electron microscopy. The equivalent circle diameter (ECD) of all 18 cases ranged from 0.40 to 1.15 microns (Mean +/- SE = 0.70 +/- 0.05 micron, median = 0.67 micron). The aspect ratio was 1.50 to 2.04 (Mean +/- SE = 1.75 +/- 0.04, median = 1.73), and roundness was 1.24 to 2.34 (Mean +/- SE = 1.61 +/- 0.07, median = 1.65). The numbers of particles were 5.2 x 10(8) to 9.17 x 10(10)/g tissue (Mean +/- SE = 1.42 x 10(10) +/- 5.41 x 10(9)/g tissue, median = 7.04 x 10(9)). The number of polyethylene (PE) particles/g tissue in TKRs was significantly larger than that in THRs (1.04 x 10(10)/g tissue and 2.16 x 10(9)/g tissue respectively, median, p = 0.03, Mann-Whitney U test). Unstable fixation of the tibial PE component might account for the accumulation of a large number of PE particles in the interface tissue.
A Kobayashi; W Bonfield; Y Kadoya; T Yamac; M A Freeman; G Scott; P A Revell
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine     Volume:  211     ISSN:  0954-4119     ISO Abbreviation:  Proc Inst Mech Eng H     Publication Date:  1997  
Date Detail:
Created Date:  1997-06-12     Completed Date:  1997-06-12     Revised Date:  2009-06-08    
Medline Journal Info:
Nlm Unique ID:  8908934     Medline TA:  Proc Inst Mech Eng H     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  11-5     Citation Subset:  IM    
Interdisciplinary Research Centre (IRC) in Biomedical Materials, Queen Mary and Westfield College, London.
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MeSH Terms
Biocompatible Materials*
Bone Cements
Knee Joint / ultrastructure
Knee Prosthesis* / adverse effects
Microscopy, Electron, Scanning
Osteolysis / etiology
Particle Size
Prosthesis Failure*
Statistics, Nonparametric
Stress, Mechanical
Reg. No./Substance:
0/Biocompatible Materials; 0/Bone Cements; 0/Plastipore; 0/Polyethylenes; 0/Polypropylenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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