| The size of adrenal incidentalomas correlates with insulin resistance. Is there a cause-effect relationship? | |
| | |
MedLine Citation:
|
PMID: 21070314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
CONTEXT: Adrenal incidentalomas (AI) have often been associated with a high prevalence of insulin resistance (IR) and cardiovascular risk factors, although direct measurement of insulin sensitivity (IS) has never been carried out. OBJECTIVE: We aimed to investigate whether the morphological and hormonal features of AI correlate with the presence and severity of IR, using the hyperinsulinaemic euglycaemic clamp (HEC). DESIGN AND MEASUREMENTS: Forty patients with AI (22 women) with a mean age of 58.5±11.1 years underwent hormonal and morphological evaluation. Nineteen patients with AI without known history of diabetes mellitus (DM) or impaired glucose tolerance (IGT) and 17 matched controls underwent oral glucose tolerance test (OGTT) and hyperinsulinaemic euglycaemic clamp (HEC). RESULTS: Diabetes mellitus was observed in 13 patients (33%), while three (8%) had IGT. Thirty-one of the AI were nonfunctioning (82.5%), whereas two (5%) secreted cortisol (Cushing's syndrome) and seven (12.5%) showed subclinical secretion of cortisol. The 19 patients with nonfunctioning AI were more insulin resistant than controls (glucose up-take: 4.58±1.80 vs 5.85±2.48 mg/kg/min respectively; P=0.01); IS was inversely related to the mass size (r=-0.57; P=0.04), free urinary cortisol (r=-0.68; P=0.01), serum cortisol after 1-mg dexamethasone suppression (-0.65; P=0.02) and percentage of trunk fat mass (-0.77; P=0.02) and directly related to serum adreno cortico tropic hormone (ACTH) (r=0.62; P=0.03). After performing multivariate regression, the mass size was found to be the most powerful predictor of IR. CONCLUSION: Our study showed a high prevalence of insulin resistance in patients with nonfunctioning AI and suggests its possible involvement in AI growth. |
| | |
Authors:
|
Giovanna Muscogiuri; Gian Pio Sorice; Annamaria Prioletta; Teresa Mezza; Clelia Cipolla; Enrica Salomone; Andrea Giaccari; Alfredo Pontecorvi; Silvia Della Casa |
Related Documents
:
|
16221474 - The l162v polymorphism at the peroxisome proliferator activated receptor alpha locus mo... 16814764 - Obesity, plasma high sensitivity c-reactive protein levels and insulin resistance statu... 20119734 - Early effects of gastric banding (lgb) and of biliopancreatic diversion (bpd) on insuli... 12149104 - Correlation of the adipocyte-derived protein adiponectin with insulin resistance index ... 21419814 - Development of redox potential-controlled schemes for very-high-gravity ethanol ferment... 11375344 - The hiv protease inhibitor nelfinavir induces insulin resistance and increases basal li... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical endocrinology Volume: 74 ISSN: 1365-2265 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-08 Completed Date: 2011-06-09 Revised Date: 2011-12-06 |
Medline Journal Info:
|
Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: England |
Other Details:
|
Languages: eng Pagination: 300-5 Citation Subset: IM |
Copyright Information:
|
© 2011 Blackwell Publishing Ltd. |
Affiliation:
|
Endocrinology and Metabolic Diseases, Catholic University-Policlinico A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy. giovanna.muscogiuri@edu.rm.unicatt.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Gland Neoplasms*
/
blood,
pathology Aged Diabetes Mellitus / diagnosis Female Glucose Clamp Technique Glucose Tolerance Test Humans Hydrocortisone / blood, urine Insulin Resistance* Male Middle Aged Multivariate Analysis Regression Analysis |
| Chemical | |
Reg. No./Substance:
|
50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Levothyroxine replacement therapy and refractory hypotension out of transitional period in preterm i...
Next Document: Psychological distress and social support are determinants of changing oral health status among an i...