Document Detail


The site of sympathetic deficit in cluster headache.
MedLine Citation:
PMID:  8666534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pattern of autonomic deficit in the face of cluster headache patients resembles the deficit in patients with a postganglionic sympathetic lesion from some other cause; however, the presence of abnormal cardiac rhythms and bilateral pupillary reflex deficit in some patients with cluster headache suggests that the lesion might compromise central sympathetic drive. To investigate this possibility, the vasomotor and sudomotor startle reflex was investigated in the hands of six cluster headache patients with ocular and thermoregulatory signs of postganglionic sympathetic deficit in the face; for comparison, responses were also investigated in 15 patients with a lesion in the cervical sympathetic pathway from some other cause. The startle reflex was intact in the hands of the six cluster headache patients, but was diminished ipsilaterally in patients with a central or preganglionic sympathetic lesion and also, surprisingly, in patients with a postganglionic lesion caused by an aneurysm of the internal carotid artery. Ocular sympathetic deficit was greater in patients with an aneurysm of the internal carotid artery than in cluster headache patients or in patients with a postganglionic sympathetic lesion from some other cause; the aneurysm may have compromised neurons with projections to the face and hand, or could have induced transsynaptic degeneration of preganglionic fibers supplying both regions. The findings indicate that central sympathetic drive is not impaired in cluster headache patients; thus, a peripheral lesion probably induces sympathetic deficit on the symptomatic side of the face.
Authors:
P D Drummond
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Headache     Volume:  36     ISSN:  0017-8748     ISO Abbreviation:  Headache     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-08-06     Completed Date:  1996-08-06     Revised Date:  2009-02-02    
Medline Journal Info:
Nlm Unique ID:  2985091R     Medline TA:  Headache     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3-9     Citation Subset:  IM    
Affiliation:
Division of Psychology, Murdoch University, Perth, Western Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Autonomic Nervous System Diseases / diagnosis,  physiopathology
Cluster Headache / physiopathology*
Female
Humans
Male
Middle Aged
Reflex
Sympathetic Nervous System / physiopathology*
Vasoconstriction

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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