Document Detail


On the site and mechanism of action of the anti-obesity effects of interleukin-6.
MedLine Citation:
PMID:  12914723     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We conducted an experimental study examining the site and mechanism of action of the anti-obesity effect of interleukin-6 (IL-6) in mice and rats. We used dual energy X-ray absorptiometry (DEXA) and computerized tomography to investigate the body composition of mice with knockout of the IL-6 gene and wild-type control mice. Rats were treated with IL-6 or vehicle through intracerebroventricular (ICV) cannulae. Energy expenditure was measured as oxygen consumption by indirect calorimetry in metabolic chambers. Results showed that the mice lacking IL-6 increased in body weight compared with wild-type mice from 6 months of age onward, although there was no marked difference in food intake between the pre-obese IL-6 knockout mice and the wild-type mice. IL-6 given as a single ICV injection to rats stimulated oxygen consumption; whereas, the same doses were ineffective when given peripherally. Chronic ICV IL-6 treatment decreased body weight and fat mass in rodents. Administration of IL-6 may decrease fat mass in mice and rats by stimulating energy expenditure at the CNS level, possibly in the hypothalamus.
Authors:
John-Olov Jansson; Kristina Wallenius; Ingrid Wernstedt; Claes Ohlsson; Suzanne L Dickson; Ville Wallenius
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society     Volume:  13 Suppl A     ISSN:  1096-6374     ISO Abbreviation:  Growth Horm. IGF Res.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-13     Completed Date:  2004-05-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9814320     Medline TA:  Growth Horm IGF Res     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  S28-32     Citation Subset:  IM    
Affiliation:
Division of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden. JOJ@medic.gu.se
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / drug effects
Animals
Anti-Obesity Agents / pharmacology*
Blood Glucose / metabolism
Body Weight / drug effects
Brain / drug effects
Energy Metabolism / drug effects
Injections, Intraventricular
Interleukin-6 / pharmacology*,  physiology
Mice
Mice, Knockout
Obesity / drug therapy,  metabolism
Oxygen Consumption / drug effects
Rats
Chemical
Reg. No./Substance:
0/Anti-Obesity Agents; 0/Blood Glucose; 0/Interleukin-6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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