Document Detail


The site of injection affects erythropoietin levels during dialysis.
MedLine Citation:
PMID:  8828781     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum concentrations of rHuEPO were measured after injection into different sites within the blood lines in patients undergoing hemodialysis. The authors compared the venous port to venous drip chamber injection using two separate delivery systems and their associated blood lines (Cobe Centry 3 [CGH, Lakewood, CO] and Fresenius A2008 [Fresenius USA, Concord, CA]). The former has a unique cartridge drip chamber and the latter a more conventional set-up. Patients were injected at both sites with their usual dose of rHuEPO at the beginning of dialysis and plasma levels were measured throughout dialysis. Significantly lower plasma levels occurred only after injection into the venous drip chamber using the Fresenius delivery system. Simultaneous samples were drawn from the venous and arterial ports and upper and lower drip chamber in a group of patients dialyzing on this system. Levels were 26 and 32 times higher in the upper and lower drip chamber compared to the venous sample, which exceeded the arterial sample. No significant rebound of rHuEPO was detected at the end of dialysis after saline rinse back in patients in whom the rHuEPO was injected into the drip chamber. The authors conclude that injection of erythropoietin into the venous drip chamber of the Fresenius delivery system should be avoided because substantial quantities are lost by "trapping," and not eluted at the end of dialysis.
Authors:
J Petersen; M S Kang; I Yeh
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  42     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1996-12-12     Completed Date:  1996-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  263-5     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Stanford University, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Enzyme-Linked Immunosorbent Assay
Erythropoietin / administration & dosage,  blood*
Humans
Injections, Intra-Arterial
Injections, Intravenous
Kidney Failure, Chronic / therapy*
Male
Middle Aged
Renal Dialysis*
Chemical
Reg. No./Substance:
11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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